BRD-K22503835_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

177 genes differentially expressed following the BRD-K22503835_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACOT7 acyl-CoA thioesterase 7
ALDOC aldolase C, fructose-bisphosphate
ATG2A autophagy related 2A
BLVRB biliverdin reductase B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C3ORF14 chromosome 3 open reading frame 14
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAPN3 calpain 3, (p94)
CCND3 cyclin D3
CD24 CD24 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CETN2 centrin, EF-hand protein, 2
CGRRF1 cell growth regulator with ring finger domain 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL5A1 collagen, type V, alpha 1
COMP cartilage oligomeric matrix protein
COTL1 coactosin-like F-actin binding protein 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTR9 CTR9, Paf1/RNA polymerase II complex component
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYBB cytochrome b-245, beta polypeptide
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
EDNRB endothelin receptor type B
EFNB2 ephrin-B2
ELOVL5 ELOVL fatty acid elongase 5
FOXJ3 forkhead box J3
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
G0S2 G0/G1 switch 2
GATA3 GATA binding protein 3
GCA grancalcin, EF-hand calcium binding protein
GLS glutaminase
GPR137B G protein-coupled receptor 137B
HIBCH 3-hydroxyisobutyryl-CoA hydrolase
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H4H histone cluster 1, H4h
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA2 heat shock 70kDa protein 2
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ICAM1 intercellular adhesion molecule 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL6ST interleukin 6 signal transducer
INHBA inhibin, beta A
KCNK3 potassium channel, two pore domain subfamily K, member 3
KRT7 keratin 7, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LIPA lipase A, lysosomal acid, cholesterol esterase
LTF lactotransferrin
MAN2B1 mannosidase, alpha, class 2B, member 1
MAST3 microtubule associated serine/threonine kinase 3
MCOLN1 mucolipin 1
MLF1 myeloid leukemia factor 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NNMT nicotinamide N-methyltransferase
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
NPY neuropeptide Y
NTS neurotensin
OAT ornithine aminotransferase
PFKM phosphofructokinase, muscle
PLA2G15 phospholipase A2, group XV
PNMA2 paraneoplastic Ma antigen 2
PRKCD protein kinase C, delta
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB31 RAB31, member RAS oncogene family
RAD9A RAD9 homolog A (S. pombe)
RGS4 regulator of G-protein signaling 4
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A9 S100 calcium binding protein A9
SCPEP1 serine carboxypeptidase 1
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SKAP2 src kinase associated phosphoprotein 2
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SNN stannin
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRGN serglycin
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAT1 signal transducer and activator of transcription 1, 91kDa
STOM stomatin
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
TBPL1 TBP-like 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM7SF2 transmembrane 7 superfamily member 2
TNC tenascin C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAK2 trafficking protein, kinesin binding 2
TUBA1A tubulin, alpha 1a
UGCG UDP-glucose ceramide glucosyltransferase
VAMP7 vesicle-associated membrane protein 7
VCAM1 vascular cell adhesion molecule 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZCCHC24 zinc finger, CCHC domain containing 24

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOA2 apolipoprotein A-II
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ATXN10 ataxin 10
BEX1 brain expressed, X-linked 1
BID BH3 interacting domain death agonist
BMP4 bone morphogenetic protein 4
CCDC86 coiled-coil domain containing 86
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CELF2 CUGBP, Elav-like family member 2
CNR1 cannabinoid receptor 1 (brain)
COMT catechol-O-methyltransferase
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DENND1B DENN/MADD domain containing 1B
DMD dystrophin
ENO1 enolase 1, (alpha)
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GRB7 growth factor receptor-bound protein 7
HMGB2 high mobility group box 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1R2 interleukin 1 receptor, type II
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MATN2 matrilin 2
MECOM MDS1 and EVI1 complex locus
MRPL3 mitochondrial ribosomal protein L3
MSLN mesothelin
MYO5C myosin VC
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
OBSL1 obscurin-like 1
PAX6 paired box 6
PDGFC platelet derived growth factor C
PDHX pyruvate dehydrogenase complex, component X
PEG3 paternally expressed 3
PGAP3 post-GPI attachment to proteins 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PROM1 prominin 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RNH1 ribonuclease/angiogenin inhibitor 1
S100A10 S100 calcium binding protein A10
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
TF transferrin
TM4SF1 transmembrane 4 L six family member 1
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TSKU tsukushi, small leucine rich proteoglycan
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
VDAC1 voltage-dependent anion channel 1
WEE1 WEE1 G2 checkpoint kinase
WNT5A wingless-type MMTV integration site family, member 5A