BRD-K22503835_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

288 genes differentially expressed following the BRD-K22503835_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AAMDC adipogenesis associated, Mth938 domain containing
ACAD8 acyl-CoA dehydrogenase family, member 8
ADAM9 ADAM metallopeptidase domain 9
ADGRF5 adhesion G protein-coupled receptor F5
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANKMY2 ankyrin repeat and MYND domain containing 2
ANKRD46 ankyrin repeat domain 46
AQP1 aquaporin 1 (Colton blood group)
ARHGAP25 Rho GTPase activating protein 25
ARHGAP29 Rho GTPase activating protein 29
ARL4C ADP-ribosylation factor-like 4C
ARMCX2 armadillo repeat containing, X-linked 2
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BZW2 basic leucine zipper and W2 domains 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CCNA1 cyclin A1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CECR1 cat eye syndrome chromosome region, candidate 1
CETN2 centrin, EF-hand protein, 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC5 chloride intracellular channel 5
CLU clusterin
CORO1A coronin, actin binding protein, 1A
CTSW cathepsin W
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOK5 docking protein 5
DSTN destrin (actin depolymerizing factor)
EAF2 ELL associated factor 2
ECHDC3 enoyl CoA hydratase domain containing 3
EFHD1 EF-hand domain family, member D1
EIF5A eukaryotic translation initiation factor 5A
ENAH enabled homolog (Drosophila)
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
FADS3 fatty acid desaturase 3
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FN1 fibronectin 1
FOXO4 forkhead box O4
G6PD glucose-6-phosphate dehydrogenase
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GCH1 GTP cyclohydrolase 1
GLRX glutaredoxin (thioltransferase)
GNAS GNAS complex locus
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GSDMB gasdermin B
GSN gelsolin
GUK1 guanylate kinase 1
HBB hemoglobin, beta
HEBP2 heme binding protein 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP5 insulin-like growth factor binding protein 5
IL17RB interleukin 17 receptor B
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KIAA0226L KIAA0226-like
LAMP2 lysosomal-associated membrane protein 2
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3 lectin, galactoside-binding, soluble, 3
LPIN1 lipin 1
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MGST3 microsomal glutathione S-transferase 3
MMP1 matrix metallopeptidase 1
MOSPD1 motile sperm domain containing 1
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
MTUS1 microtubule associated tumor suppressor 1
MX1 MX dynamin-like GTPase 1
NARF nuclear prelamin A recognition factor
NDRG1 N-myc downstream regulated 1
NEU1 sialidase 1 (lysosomal sialidase)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLA2G15 phospholipase A2, group XV
PLIN2 perilipin 2
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
ROGDI rogdi homolog (Drosophila)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCPEP1 serine carboxypeptidase 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SRGN serglycin
SST somatostatin
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TFRC transferrin receptor
TIMP3 TIMP metallopeptidase inhibitor 3
TM7SF2 transmembrane 7 superfamily member 2
TMEM110 transmembrane protein 110
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TUBA4A tubulin, alpha 4a
TUFT1 tuftelin 1
TYROBP TYRO protein tyrosine kinase binding protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACP6 acid phosphatase 6, lysophosphatidic
ACTN1 actinin, alpha 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADORA2B adenosine A2b receptor
AKAP8 A kinase (PRKA) anchor protein 8
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
ATP13A3 ATPase type 13A3
AURKA aurora kinase A
BEX1 brain expressed, X-linked 1
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CNR1 cannabinoid receptor 1 (brain)
CXCL8 chemokine (C-X-C motif) ligand 8
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DCTD dCMP deaminase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DUT deoxyuridine triphosphatase
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EREG epiregulin
EXOSC4 exosome component 4
F12 coagulation factor XII (Hageman factor)
FAM216A family with sequence similarity 216, member A
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FLT3 fms-related tyrosine kinase 3
FOSL1 FOS-like antigen 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GOSR1 golgi SNAP receptor complex member 1
GPX2 glutathione peroxidase 2
GRWD1 glutamate-rich WD repeat containing 1
GSAP gamma-secretase activating protein
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HOXB7 homeobox B7
HOXC6 homeobox C6
IGF1R insulin-like growth factor 1 receptor
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP6 insulin-like growth factor binding protein 6
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KIF14 kinesin family member 14
KLF9 Kruppel-like factor 9
KPNB1 karyopherin (importin) beta 1
KYNU kynureninase
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LCMT2 leucine carboxyl methyltransferase 2
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MCTP1 multiple C2 domains, transmembrane 1
MICALL1 MICAL-like 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOK MOK protein kinase
MSL1 male-specific lethal 1 homolog (Drosophila)
NBN nibrin
NCOR2 nuclear receptor corepressor 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLGN4X neuroligin 4, X-linked
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
PARP2 poly (ADP-ribose) polymerase 2
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PGLS 6-phosphogluconolactonase
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PIR pirin (iron-binding nuclear protein)
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PRR7 proline rich 7 (synaptic)
PRSS23 protease, serine, 23
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAB13 RAB13, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPP25 ribonuclease P/MRP 25kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC25A46 solute carrier family 25, member 46
SMAD3 SMAD family member 3
SMAGP small cell adhesion glycoprotein
SPRY2 sprouty homolog 2 (Drosophila)
STARD13 StAR-related lipid transfer (START) domain containing 13
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUMO3 small ubiquitin-like modifier 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCERG1 transcription elongation regulator 1
TCF12 transcription factor 12
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMF1 TATA element modulatory factor 1
TMPO thymopoietin
TNC tenascin C
TP53 tumor protein p53
TRIM44 tripartite motif containing 44
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN8 tetraspanin 8
TUBGCP3 tubulin, gamma complex associated protein 3
UBE2E3 ubiquitin-conjugating enzyme E2E 3
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VCAN versican
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZC3H4 zinc finger CCCH-type containing 4
ZHX2 zinc fingers and homeoboxes 2