BRD-K22227508_l-ornithine, n5-[imino(methylamino)methyl]-[cas]_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

187 genes differentially expressed following the BRD-K22227508_l-ornithine, n5-[imino(methylamino)methyl]-[cas]_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABAT 4-aminobutyrate aminotransferase
ACAA1 acetyl-CoA acyltransferase 1
ACKR3 atypical chemokine receptor 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALB albumin
ALOX15B arachidonate 15-lipoxygenase, type B
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ASCL1 achaete-scute family bHLH transcription factor 1
ATP11B ATPase, class VI, type 11B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BGN biglycan
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CCND2 cyclin D2
CD300A CD300a molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CEP57 centrosomal protein 57kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC2B C-type lectin domain family 2, member B
COL8A2 collagen, type VIII, alpha 2
CORO1A coronin, actin binding protein, 1A
CPE carboxypeptidase E
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
DACT1 dishevelled-binding antagonist of beta-catenin 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
ENOPH1 enolase-phosphatase 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPCAM epithelial cell adhesion molecule
ESRP1 epithelial splicing regulatory protein 1
FAP fibroblast activation protein, alpha
FERMT1 fermitin family member 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FILIP1L filamin A interacting protein 1-like
FRZB frizzled-related protein
FST follistatin
G0S2 G0/G1 switch 2
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
GSTZ1 glutathione S-transferase zeta 1
HDAC9 histone deacetylase 9
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2BD histone cluster 1, H2bd
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HOPX HOP homeobox
HTRA1 HtrA serine peptidase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IL1B interleukin 1, beta
IL32 interleukin 32
INSIG1 insulin induced gene 1
IQGAP1 IQ motif containing GTPase activating protein 1
ITM2A integral membrane protein 2A
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT19 keratin 19, type I
LAPTM5 lysosomal protein transmembrane 5
LIN28A lin-28 homolog A (C. elegans)
LRRC15 leucine rich repeat containing 15
LRRC17 leucine rich repeat containing 17
MAP7 microtubule-associated protein 7
MFAP5 microfibrillar associated protein 5
MPPED2 metallophosphoesterase domain containing 2
MYL9 myosin, light chain 9, regulatory
NANOG Nanog homeobox
NGRN neugrin, neurite outgrowth associated
NPTX2 neuronal pentraxin II
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRCAM neuronal cell adhesion molecule
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PBX3 pre-B-cell leukemia homeobox 3
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PLAU plasminogen activator, urokinase
PLN phospholamban
PLS3 plastin 3
PTK2B protein tyrosine kinase 2 beta
PTN pleiotrophin
RAB25 RAB25, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RB1 retinoblastoma 1
RFTN1 raftlin, lipid raft linker 1
RNASE6 ribonuclease, RNase A family, k6
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS5 ribosomal protein S5
SC5D sterol-C5-desaturase
SCGB1D2 secretoglobin, family 1D, member 2
SCN3A sodium channel, voltage gated, type III alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP4 secreted frizzled-related protein 4
SGCE sarcoglycan, epsilon
SNAI2 snail family zinc finger 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX7 sorting nexin 7
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT1 serine peptidase inhibitor, Kunitz type 1
SST somatostatin
STON1 stonin 1
SULF1 sulfatase 1
TGFB3 transforming growth factor, beta 3
THBS2 thrombospondin 2
TM9SF3 transmembrane 9 superfamily member 3
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMEM30B transmembrane protein 30B
VNN1 vanin 1
XIST X inactive specific transcript (non-protein coding)
ZNF589 zinc finger protein 589
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
BST2 bone marrow stromal cell antigen 2
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CAPNS1 calpain, small subunit 1
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD81 CD81 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPE centromere protein E, 312kDa
CLCN3 chloride channel, voltage-sensitive 3
CLU clusterin
CSNK1A1 casein kinase 1, alpha 1
CSTA cystatin A (stefin A)
DEFB1 defensin, beta 1
EMP3 epithelial membrane protein 3
ENO2 enolase 2 (gamma, neuronal)
EVL Enah/Vasp-like
FAM57A family with sequence similarity 57, member A
FOLR1 folate receptor 1 (adult)
GRB14 growth factor receptor-bound protein 14
GRN granulin
GSTA4 glutathione S-transferase alpha 4
KIF5B kinesin family member 5B
LIMS1 LIM and senescent cell antigen-like domains 1
LTBP3 latent transforming growth factor beta binding protein 3
LY6D lymphocyte antigen 6 complex, locus D
LY6E lymphocyte antigen 6 complex, locus E
MBOAT7 membrane bound O-acyltransferase domain containing 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MTUS1 microtubule associated tumor suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFE2L2 nuclear factor, erythroid 2-like 2
ODAM odontogenic, ameloblast asssociated
PLAT plasminogen activator, tissue
PMP22 peripheral myelin protein 22
PPAP2C phosphatidic acid phosphatase type 2C
PRAME preferentially expressed antigen in melanoma
PRKCA protein kinase C, alpha
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPL39L ribosomal protein L39-like
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SPTBN1 spectrin, beta, non-erythrocytic 1
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGM2 transglutaminase 2
TSC22D1 TSC22 domain family, member 1
TSPAN13 tetraspanin 13
WFDC2 WAP four-disulfide core domain 2