BRD-K22096725_ALW-II-49-7_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K22096725_ALW-II-49-7_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANXA3 annexin A3
CD81 CD81 molecule
CDA cytidine deaminase
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP6 dual specificity phosphatase 6
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL5 ELOVL fatty acid elongase 5
FABP4 fatty acid binding protein 4, adipocyte
GAL galanin/GMAP prepropeptide
GLRX glutaredoxin (thioltransferase)
GREM1 gremlin 1, DAN family BMP antagonist
IER3 immediate early response 3
ITGB5 integrin, beta 5
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KDM5D lysine (K)-specific demethylase 5D
KRT18 keratin 18, type I
LIF leukemia inhibitory factor
MAB21L2 mab-21-like 2 (C. elegans)
MAP1B microtubule-associated protein 1B
NAMPT nicotinamide phosphoribosyltransferase
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SOX4 SRY (sex determining region Y)-box 4
SRGN serglycin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TGM2 transglutaminase 2
TUBB6 tubulin, beta 6 class V

decreased expression

Symbol Name
AFP alpha-fetoprotein
AHSG alpha-2-HS-glycoprotein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANPEP alanyl (membrane) aminopeptidase
BEX1 brain expressed, X-linked 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD24 CD24 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLCA2 chloride channel accessory 2
CLU clusterin
CPB1 carboxypeptidase B1 (tissue)
CSTA cystatin A (stefin A)
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMD dystrophin
DUSP22 dual specificity phosphatase 22
EGFR epidermal growth factor receptor
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FST follistatin
GPC3 glypican 3
GSTA1 glutathione S-transferase alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IPO13 importin 13
KIAA0101 KIAA0101
KLK5 kallikrein-related peptidase 5
KRT5 keratin 5, type II
MAGED1 melanoma antigen family D1
METTL7A methyltransferase like 7A
MPZL2 myelin protein zero-like 2
NFE2L2 nuclear factor, erythroid 2-like 2
PAH phenylalanine hydroxylase
PDGFC platelet derived growth factor C
PEG3 paternally expressed 3
PPL periplakin
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTN pleiotrophin
RAD23B RAD23 homolog B (S. cerevisiae)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SFRP1 secreted frizzled-related protein 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQLE squalene epoxidase
TF transferrin
TMEM97 transmembrane protein 97
TSPAN7 tetraspanin 7
TYMS thymidylate synthetase
XIST X inactive specific transcript (non-protein coding)