BRD-K22010301_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K22010301_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ATF3 activating transcription factor 3
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CAV1 caveolin 1, caveolae protein, 22kDa
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEP57 centrosomal protein 57kDa
CES1 carboxylesterase 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CXORF57 chromosome X open reading frame 57
CYB5A cytochrome b5 type A (microsomal)
DDIT4 DNA-damage-inducible transcript 4
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
INSIG1 insulin induced gene 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MT1M metallothionein 1M
NAMPT nicotinamide phosphoribosyltransferase
NEB nebulin
NQO1 NAD(P)H dehydrogenase, quinone 1
PGD phosphogluconate dehydrogenase
PIR pirin (iron-binding nuclear protein)
POPDC3 popeye domain containing 3
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCQ protein kinase C, theta
PSAP prosaposin
RGCC regulator of cell cycle
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SFN stratifin
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPARCL1 SPARC-like 1 (hevin)
SQSTM1 sequestosome 1
TMEM45A transmembrane protein 45A
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXN thioredoxin
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
AREG amphiregulin
CBFB core-binding factor, beta subunit
CCL4 chemokine (C-C motif) ligand 4
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLDN3 claudin 3
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
EGR3 early growth response 3
FAM63A family with sequence similarity 63, member A
GBP1 guanylate binding protein 1, interferon-inducible
GNAS GNAS complex locus
LTF lactotransferrin
MXRA7 matrix-remodelling associated 7
NFIB nuclear factor I/B
NR4A2 nuclear receptor subfamily 4, group A, member 2
PEBP1 phosphatidylethanolamine binding protein 1
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
POSTN periostin, osteoblast specific factor
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTMA prothymosin, alpha
RHOBTB3 Rho-related BTB domain containing 3
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TLR4 toll-like receptor 4
TRPS1 trichorhinophalangeal syndrome I