BRD-K21680192_mitoxantrone_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

337 genes differentially expressed following the BRD-K21680192_mitoxantrone_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRE5 adhesion G protein-coupled receptor E5
ADM adrenomedullin
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
AMPD3 adenosine monophosphate deaminase 3
ANXA5 annexin A5
APOC1 apolipoprotein C-I
APOE apolipoprotein E
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
ATF5 activating transcription factor 5
BAMBI BMP and activin membrane-bound inhibitor
BHLHE40 basic helix-loop-helix family, member e40
BTBD3 BTB (POZ) domain containing 3
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CBR3 carbonyl reductase 3
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD83 CD83 molecule
CD9 CD9 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEMIP cell migration inducing protein, hyaluronan binding
CES1 carboxylesterase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN2 chimerin 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLGN calmegin
CLU clusterin
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CPM carboxypeptidase M
CTGF connective tissue growth factor
CTSS cathepsin S
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CYB5R2 cytochrome b5 reductase 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYR61 cysteine-rich, angiogenic inducer, 61
CYTH1 cytohesin 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DEFB1 defensin, beta 1
DFNA5 deafness, autosomal dominant 5
DLX2 distal-less homeobox 2
DPYSL2 dihydropyrimidinase-like 2
DSE dermatan sulfate epimerase
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EGR2 early growth response 2
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EMX2 empty spiracles homeobox 2
ERO1L ERO1-like (S. cerevisiae)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F3 coagulation factor III (thromboplastin, tissue factor)
F8 coagulation factor VIII, procoagulant component
FBLN1 fibulin 1
FERMT2 fermitin family member 2
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FZD6 frizzled class receptor 6
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS7 growth arrest-specific 7
GBE1 glucan (1,4-alpha-), branching enzyme 1
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GLRX glutaredoxin (thioltransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GULP1 GULP, engulfment adaptor PTB domain containing 1
HACD1 3-hydroxyacyl-CoA dehydratase 1
HCK HCK proto-oncogene, Src family tyrosine kinase
HDAC9 histone deacetylase 9
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HRH1 histamine receptor H1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
IER5 immediate early response 5
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFIH1 interferon induced with helicase C domain 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IL18 interleukin 18
IL1RN interleukin 1 receptor antagonist
IL32 interleukin 32
IL6 interleukin 6
ISG20 interferon stimulated exonuclease gene 20kDa
ITM2C integral membrane protein 2C
JAG1 jagged 1
JUN jun proto-oncogene
KLF11 Kruppel-like factor 11
KLF4 Kruppel-like factor 4 (gut)
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LAMP3 lysosomal-associated membrane protein 3
LCN2 lipocalin 2
LPXN leupaxin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCO macrophage receptor with collagenous structure
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MTSS1 metastasis suppressor 1
MUC16 mucin 16, cell surface associated
MYLIP myosin regulatory light chain interacting protein
NCF2 neutrophil cytosolic factor 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NPAS2 neuronal PAS domain protein 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP3 nuclear receptor interacting protein 3
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PALLD palladin, cytoskeletal associated protein
PDE4A phosphodiesterase 4A, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PER2 period circadian clock 2
PGBD5 piggyBac transposable element derived 5
PI3 peptidase inhibitor 3, skin-derived
PLAGL1 pleiomorphic adenoma gene-like 1
PLTP phospholipid transfer protein
PNMA2 paraneoplastic Ma antigen 2
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGES prostaglandin E synthase
PTN pleiotrophin
PTX3 pentraxin 3, long
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBKS ribokinase
RCAN1 regulator of calcineurin 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFTN1 raftlin, lipid raft linker 1
RRAGD Ras-related GTP binding D
RTP4 receptor (chemosensory) transporter protein 4
S100A9 S100 calcium binding protein A9
SCRN1 secernin 1
SDC4 syndecan 4
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC43A3 solute carrier family 43, member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPRY2 sprouty homolog 2 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBX3 T-box 3
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFRC transferrin receptor
TGM2 transglutaminase 2
TIMP1 TIMP metallopeptidase inhibitor 1
TKTL1 transketolase-like 1
TMEM2 transmembrane protein 2
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNS3 tensin 3
TPBG trophoblast glycoprotein
TRIB2 tribbles pseudokinase 2
TSPAN3 tetraspanin 3
TSPAN7 tetraspanin 7
TUBB2B tubulin, beta 2B class IIb
TUBB6 tubulin, beta 6 class V
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
USP11 ubiquitin specific peptidase 11
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADD3 adducin 3 (gamma)
AGR2 anterior gradient 2
AHNAK AHNAK nucleoprotein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BRD7 bromodomain containing 7
CA2 carbonic anhydrase II
CCND2 cyclin D2
CCNF cyclin F
CD36 CD36 molecule (thrombospondin receptor)
CDC20 cell division cycle 20
CENPF centromere protein F, 350/400kDa
CHEK2 checkpoint kinase 2
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL4A5 collagen, type IV, alpha 5
CPE carboxypeptidase E
CPT1A carnitine palmitoyltransferase 1A (liver)
CRIP2 cysteine-rich protein 2
CRYM crystallin, mu
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTL1 cytokine-like 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCK deoxycytidine kinase
DCXR dicarbonyl/L-xylulose reductase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ECD ecdysoneless homolog (Drosophila)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPRS glutamyl-prolyl-tRNA synthetase
F13A1 coagulation factor XIII, A1 polypeptide
FASN fatty acid synthase
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GLOD4 glyoxalase domain containing 4
GNPDA1 glucosamine-6-phosphate deaminase 1
GRB14 growth factor receptor-bound protein 14
H2AFV H2A histone family, member V
HADH hydroxyacyl-CoA dehydrogenase
HBB hemoglobin, beta
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1L hematological and neurological expressed 1-like
HOXB2 homeobox B2
HOXB6 homeobox B6
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM2 interferon induced transmembrane protein 2
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
JAG2 jagged 2
JCHAIN joining chain of multimeric IgA and IgM
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM5D lysine (K)-specific demethylase 5D
KIF20A kinesin family member 20A
KLK11 kallikrein-related peptidase 11
KRT18 keratin 18, type I
LTB lymphotoxin beta (TNF superfamily, member 3)
LYPLA1 lysophospholipase I
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MSMO1 methylsterol monooxygenase 1
MTA1 metastasis associated 1
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NELL2 NEL-like 2 (chicken)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPDC1 neural proliferation, differentiation and control, 1
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTS neurotensin
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PEBP1 phosphatidylethanolamine binding protein 1
PIP prolactin-induced protein
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK1 polo-like kinase 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRC1 protein regulator of cytokinesis 1
PROM1 prominin 1
PSIP1 PC4 and SFRS1 interacting protein 1
PWP1 PWP1 homolog (S. cerevisiae)
PYCR1 pyrroline-5-carboxylate reductase 1
RAMP3 receptor (G protein-coupled) activity modifying protein 3
RBM47 RNA binding motif protein 47
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RHOA ras homolog family member A
RPS4Y1 ribosomal protein S4, Y-linked 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELL selectin L
SEPW1 selenoprotein W, 1
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPDEF SAM pointed domain containing ETS transcription factor
SPP1 secreted phosphoprotein 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK17B serine/threonine kinase 17b
TACC3 transforming, acidic coiled-coil containing protein 3
TARP TCR gamma alternate reading frame protein
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFB3 transforming growth factor, beta 3
TM9SF3 transmembrane 9 superfamily member 3
TMEM123 transmembrane protein 123
TNIK TRAF2 and NCK interacting kinase
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TSTA3 tissue specific transplantation antigen P35B
TTC3 tetratricopeptide repeat domain 3
VCAN versican
VDAC1 voltage-dependent anion channel 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WASF2 WAS protein family, member 2
XBP1 X-box binding protein 1