BRD-K21680192_mitoxantrone_SKBR3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

213 genes differentially expressed following the BRD-K21680192_mitoxantrone_SKBR3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ADD3 adducin 3 (gamma)
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BIRC3 baculoviral IAP repeat containing 3
C10ORF10 chromosome 10 open reading frame 10
CA1 carbonic anhydrase I
CAV1 caveolin 1, caveolae protein, 22kDa
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CCNE1 cyclin E1
CCNE2 cyclin E2
CCP110 centriolar coiled coil protein 110kDa
CD24 CD24 molecule
CD38 CD38 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CENPU centromere protein U
COL14A1 collagen, type XIV, alpha 1
COL5A2 collagen, type V, alpha 2
CSRP1 cysteine and glycine-rich protein 1
CSRP2 cysteine and glycine-rich protein 2
CTSS cathepsin S
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMD dystrophin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP5 dual specificity phosphatase 5
EDN1 endothelin 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAM129A family with sequence similarity 129, member A
FBLN1 fibulin 1
FGFR3 fibroblast growth factor receptor 3
FHL2 four and a half LIM domains 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA6 GATA binding protein 6
GBP1 guanylate binding protein 1, interferon-inducible
GCH1 GTP cyclohydrolase 1
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HDAC9 histone deacetylase 9
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICAM1 intercellular adhesion molecule 1
IFI27 interferon, alpha-inducible protein 27
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGKV1-5 immunoglobulin kappa variable 1-5
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL32 interleukin 32
IL6ST interleukin 6 signal transducer
IRF1 interferon regulatory factor 1
JCHAIN joining chain of multimeric IgA and IgM
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LCN2 lipocalin 2
LOXL1 lysyl oxidase-like 1
LRRN3 leucine rich repeat neuronal 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NAV2 neuron navigator 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
OPTN optineurin
PALLD palladin, cytoskeletal associated protein
PLAU plasminogen activator, urokinase
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIN2 Ras and Rab interactor 2
RNF19B ring finger protein 19B
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SDC4 syndecan 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SGK1 serum/glucocorticoid regulated kinase 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMAD3 SMAD family member 3
SOCS1 suppressor of cytokine signaling 1
SOD2 superoxide dismutase 2, mitochondrial
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TLE4 transducin-like enhancer of split 4
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP63 tumor protein p63
TRAF1 TNF receptor-associated factor 1
TSKU tsukushi, small leucine rich proteoglycan
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
TYMP thymidine phosphorylase
VCAM1 vascular cell adhesion molecule 1
VIM vimentin

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AGR2 anterior gradient 2
ARG2 arginase 2
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPN asporin
ASRGL1 asparaginase like 1
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
C1QB complement component 1, q subcomponent, B chain
C6ORF62 chromosome 6 open reading frame 62
CD14 CD14 molecule
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD46 CD46 molecule, complement regulatory protein
CD93 CD93 molecule
CDC20 cell division cycle 20
CLEC11A C-type lectin domain family 11, member A
COL18A1 collagen, type XVIII, alpha 1
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRIP2 cysteine-rich protein 2
CSF1R colony stimulating factor 1 receptor
CTSC cathepsin C
CXCL14 chemokine (C-X-C motif) ligand 14
DACH1 dachshund family transcription factor 1
DBN1 drebrin 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPCAM epithelial cell adhesion molecule
FABP4 fatty acid binding protein 4, adipocyte
FXR1 fragile X mental retardation, autosomal homolog 1
GMDS GDP-mannose 4,6-dehydratase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GRB14 growth factor receptor-bound protein 14
GRB7 growth factor receptor-bound protein 7
GRIA2 glutamate receptor, ionotropic, AMPA 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
KCTD12 potassium channel tetramerization domain containing 12
KIF20A kinesin family member 20A
LPL lipoprotein lipase
LPXN leupaxin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MSX1 msh homeobox 1
MYO5C myosin VC
NEBL nebulette
NFIB nuclear factor I/B
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPY1R neuropeptide Y receptor Y1
OBSL1 obscurin-like 1
PCDH9 protocadherin 9
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLK1 polo-like kinase 1
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PROM1 prominin 1
PTPRC protein tyrosine phosphatase, receptor type, C
RAD51C RAD51 paralog C
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SATB1 SATB homeobox 1
SCAND1 SCAN domain containing 1
SEPP1 selenoprotein P, plasma, 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX11 SRY (sex determining region Y)-box 11
SPDEF SAM pointed domain containing ETS transcription factor
SPEN spen family transcriptional repressor
SPP1 secreted phosphoprotein 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFB3 transforming growth factor, beta 3
TGFBI transforming growth factor, beta-induced, 68kDa
TMSB15A thymosin beta 15a
TPBG trophoblast glycoprotein
TRPS1 trichorhinophalangeal syndrome I
TYROBP TYRO protein tyrosine kinase binding protein
VCAN versican
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1
VWF von Willebrand factor
XBP1 X-box binding protein 1