BRD-K21680192_mitoxantrone_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

324 genes differentially expressed following the BRD-K21680192_mitoxantrone_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD6 abhydrolase domain containing 6
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ADGRG2 adhesion G protein-coupled receptor G2
AKAP8L A kinase (PRKA) anchor protein 8-like
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF5 activating transcription factor 5
BAG1 BCL2-associated athanogene
BAMBI BMP and activin membrane-bound inhibitor
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BECN1 beclin 1, autophagy related
BMP4 bone morphogenetic protein 4
BRCA1 breast cancer 1, early onset
BRD4 bromodomain containing 4
BST2 bone marrow stromal cell antigen 2
BTG2 BTG family, member 2
C1ORF54 chromosome 1 open reading frame 54
C9ORF3 chromosome 9 open reading frame 3
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CCNE2 cyclin E2
CD37 CD37 molecule
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD83 CD83 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEMIP cell migration inducing protein, hyaluronan binding
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN1 claudin 1
CLGN calmegin
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CRIP1 cysteine-rich protein 1 (intestinal)
CRYAB crystallin, alpha B
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
CXCL2 chemokine (C-X-C motif) ligand 2
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DUSP10 dual specificity phosphatase 10
EDN1 endothelin 1
EIF1B eukaryotic translation initiation factor 1B
EMX2 empty spiracles homeobox 2
FAM134A family with sequence similarity 134, member A
FBN1 fibrillin 1
FILIP1L filamin A interacting protein 1-like
FZD7 frizzled class receptor 7
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAS1 growth arrest-specific 1
GDF15 growth differentiation factor 15
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAS GNAS complex locus
GNLY granulysin
GOLGA8H golgin A8 family, member H
GPX7 glutathione peroxidase 7
H1F0 H1 histone family, member 0
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HOPX HOP homeobox
HOXC6 homeobox C6
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IL6 interleukin 6
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
JOSD1 Josephin domain containing 1
JUN jun proto-oncogene
JUND jun D proto-oncogene
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KIAA0907 KIAA0907
KIF5C kinesin family member 5C
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KRT17 keratin 17, type I
LAMP3 lysosomal-associated membrane protein 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
MBD4 methyl-CpG binding domain protein 4
MCAM melanoma cell adhesion molecule
MCOLN1 mucolipin 1
MEOX2 mesenchyme homeobox 2
MIR22HG MIR22 host gene
MOAP1 modulator of apoptosis 1
MT1E metallothionein 1E
MT1M metallothionein 1M
MX1 MX dynamin-like GTPase 1
MXRA5 matrix-remodelling associated 5
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NLRP2 NLR family, pyrin domain containing 2
NOTCH1 notch 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OASL 2'-5'-oligoadenylate synthetase-like
OLFM1 olfactomedin 1
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
PARP12 poly (ADP-ribose) polymerase family, member 12
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PER2 period circadian clock 2
PLSCR4 phospholipid scramblase 4
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTN pleiotrophin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBP1 retinol binding protein 1, cellular
REG1A regenerating islet-derived 1 alpha
RFC4 replication factor C (activator 1) 4, 37kDa
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RUNX3 runt-related transcription factor 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SOD2 superoxide dismutase 2, mitochondrial
SPAG4 sperm associated antigen 4
SPON2 spondin 2, extracellular matrix protein
SRSF7 serine/arginine-rich splicing factor 7
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT4 signal transducer and activator of transcription 4
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like
SYNE2 spectrin repeat containing, nuclear envelope 2
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TCTA T-cell leukemia translocation altered
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TKTL1 transketolase-like 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOB1 transducer of ERBB2, 1
TPPP3 tubulin polymerization-promoting protein family member 3
TRD T cell receptor delta locus
TSPYL2 TSPY-like 2
TUFT1 tuftelin 1
UBE3B ubiquitin protein ligase E3B
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VSNL1 visinin-like 1
YBX3 Y box binding protein 3
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABR active BCR-related
ADGRG6 adhesion G protein-coupled receptor G6
AIM1 absent in melanoma 1
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALCAM activated leukocyte cell adhesion molecule
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
ANXA10 annexin A10
ANXA3 annexin A3
ANXA5 annexin A5
APOD apolipoprotein D
ASCC3 activating signal cointegrator 1 complex subunit 3
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BASP1 brain abundant, membrane attached signal protein 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CAPG capping protein (actin filament), gelsolin-like
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNF cyclin F
CD14 CD14 molecule
CD59 CD59 molecule, complement regulatory protein
CDK14 cyclin-dependent kinase 14
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPF centromere protein F, 350/400kDa
CHMP6 charged multivesicular body protein 6
CREB3L1 cAMP responsive element binding protein 3-like 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRTAP cartilage associated protein
CRYM crystallin, mu
CSTA cystatin A (stefin A)
CTSE cathepsin E
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ECD ecdysoneless homolog (Drosophila)
ENO1 enolase 1, (alpha)
EPRS glutamyl-prolyl-tRNA synthetase
ERO1L ERO1-like (S. cerevisiae)
FBP1 fructose-1,6-bisphosphatase 1
FCGBP Fc fragment of IgG binding protein
FCHSD2 FCH and double SH3 domains 2
FERMT1 fermitin family member 1
FHOD3 formin homology 2 domain containing 3
FSTL1 follistatin-like 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GSTO1 glutathione S-transferase omega 1
HBE1 hemoglobin, epsilon 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGA2 high mobility group AT-hook 2
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INSIG1 insulin induced gene 1
ITGA6 integrin, alpha 6
JCHAIN joining chain of multimeric IgA and IgM
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KRT15 keratin 15, type I
KRT19 keratin 19, type I
LAMA3 laminin, alpha 3
LGALS4 lectin, galactoside-binding, soluble, 4
LOXL1 lysyl oxidase-like 1
LTF lactotransferrin
LYPLA1 lysophospholipase I
LYZ lysozyme
MAP1B microtubule-associated protein 1B
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MARCKS myristoylated alanine-rich protein kinase C substrate
MEIS2 Meis homeobox 2
METTL9 methyltransferase like 9
MGLL monoglyceride lipase
MKL2 MKL/myocardin-like 2
MLPH melanophilin
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MYOF myoferlin
NARFL nuclear prelamin A recognition factor-like
NME4 NME/NM23 nucleoside diphosphate kinase 4
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
OLFM4 olfactomedin 4
OXTR oxytocin receptor
PAM peptidylglycine alpha-amidating monooxygenase
PCLO piccolo presynaptic cytomatrix protein
PFKL phosphofructokinase, liver
PGAM1 phosphoglycerate mutase 1 (brain)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP prolactin-induced protein
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLK1 polo-like kinase 1
PMP22 peripheral myelin protein 22
PPA1 pyrophosphatase (inorganic) 1
PPARG peroxisome proliferator-activated receptor gamma
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PROM1 prominin 1
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PSCA prostate stem cell antigen
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RDX radixin
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEPHS1 selenophosphate synthetase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC35F2 solute carrier family 35, member F2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLIT2 slit homolog 2 (Drosophila)
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SNX10 sorting nexin 10
SORD sorbitol dehydrogenase
SPDEF SAM pointed domain containing ETS transcription factor
SPINK1 serine peptidase inhibitor, Kazal type 1
SQRDL sulfide quinone reductase-like (yeast)
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
SVIL supervillin
TBC1D5 TBC1 domain family, member 5
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM9SF3 transmembrane 9 superfamily member 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNIK TRAF2 and NCK interacting kinase
TOP2B topoisomerase (DNA) II beta 180kDa
TPBG trophoblast glycoprotein
TSPAN4 tetraspanin 4
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A
ZNF395 zinc finger protein 395