BRD-K21680192_mitoxantrone_MDAMB231_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

210 genes differentially expressed following the BRD-K21680192_mitoxantrone_MDAMB231_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AGRN agrin
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APLP2 amyloid beta (A4) precursor-like protein 2
APOC1 apolipoprotein C-I
APOE apolipoprotein E
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BCAM basal cell adhesion molecule (Lutheran blood group)
BLNK B-cell linker
C2CD2 C2 calcium-dependent domain containing 2
C3 complement component 3
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CD1E CD1e molecule
CD200 CD200 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CEMIP cell migration inducing protein, hyaluronan binding
CHN1 chimerin 1
CHN2 chimerin 2
CLC Charcot-Leyden crystal galectin
CLEC5A C-type lectin domain family 5, member A
COL11A1 collagen, type XI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CXCL5 chemokine (C-X-C motif) ligand 5
CYB5A cytochrome b5 type A (microsomal)
CYBB cytochrome b-245, beta polypeptide
EGR1 early growth response 1
EMX2 empty spiracles homeobox 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FBLN1 fibulin 1
FECH ferrochelatase
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
H1F0 H1 histone family, member 0
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INHBA inhibin, beta A
ISYNA1 inositol-3-phosphate synthase 1
ITGAV integrin, alpha V
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT7 keratin 7, type II
LCN2 lipocalin 2
LDOC1 leucine zipper, down-regulated in cancer 1
LOC100505650 uncharacterized LOC100505650
MAN1A1 mannosidase, alpha, class 1A, member 1
MEIS2 Meis homeobox 2
METTL7A methyltransferase like 7A
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MX1 MX dynamin-like GTPase 1
NMB neuromedin B
NOTCH3 notch 3
PECAM1 platelet/endothelial cell adhesion molecule 1
PON2 paraoxonase 2
PRKCH protein kinase C, eta
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PXDN peroxidasin
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGCC regulator of cell cycle
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SDC2 syndecan 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SNAP25 synaptosomal-associated protein, 25kDa
SPINK1 serine peptidase inhibitor, Kazal type 1
SYNGR3 synaptogyrin 3
THY1 Thy-1 cell surface antigen
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TPGS2 tubulin polyglutamylase complex subunit 2
TSPAN13 tetraspanin 13
TUSC3 tumor suppressor candidate 3
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
AK4 adenylate kinase 4
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARL4C ADP-ribosylation factor-like 4C
ARPP19 cAMP-regulated phosphoprotein, 19kDa
AUTS2 autism susceptibility candidate 2
AXL AXL receptor tyrosine kinase
BHLHE40 basic helix-loop-helix family, member e40
BIN1 bridging integrator 1
CCNF cyclin F
CD24 CD24 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDCA4 cell division cycle associated 4
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CLEC2B C-type lectin domain family 2, member B
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DST dystonin
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
EIF5 eukaryotic translation initiation factor 5
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERBB2IP erbb2 interacting protein
EREG epiregulin
F2R coagulation factor II (thrombin) receptor
F3 coagulation factor III (thromboplastin, tissue factor)
FAS Fas cell surface death receptor
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FSTL1 follistatin-like 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FZD7 frizzled class receptor 7
GATA3 GATA binding protein 3
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAS GNAS complex locus
GPM6B glycoprotein M6B
HMGA2 high mobility group AT-hook 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IL32 interleukin 32
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JADE2 jade family PHD finger 2
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KLF5 Kruppel-like factor 5 (intestinal)
LUM lumican
MACF1 microtubule-actin crosslinking factor 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MCL1 myeloid cell leukemia 1
MKL2 MKL/myocardin-like 2
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLPH melanophilin
MT1X metallothionein 1X
MT2A metallothionein 2A
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV2 neuron navigator 2
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NKX3-1 NK3 homeobox 1
NOTCH2 notch 2
OLFM4 olfactomedin 4
PARP8 poly (ADP-ribose) polymerase family, member 8
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP prolactin-induced protein
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLK2 polo-like kinase 2
PLP1 proteolipid protein 1
POSTN periostin, osteoblast specific factor
PPAP2B phosphatidic acid phosphatase type 2B
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RFTN1 raftlin, lipid raft linker 1
RPS11 ribosomal protein S11
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SFRP1 secreted frizzled-related protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SOBP sine oculis binding protein homolog (Drosophila)
SOCS1 suppressor of cytokine signaling 1
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS4 thrombospondin 4
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNS3 tensin 3
TUBB2A tubulin, beta 2A class IIa
UGCG UDP-glucose ceramide glucosyltransferase
VGLL4 vestigial-like family member 4
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WEE1 WEE1 G2 checkpoint kinase
ZFP36L1 ZFP36 ring finger protein-like 1