BRD-K21680192_mitoxantrone_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K21680192_mitoxantrone_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
BTG2 BTG family, member 2
CA11 carbonic anhydrase XI
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
DUSP10 dual specificity phosphatase 10
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
GJA1 gap junction protein, alpha 1, 43kDa
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HP haptoglobin
IGLL1 immunoglobulin lambda-like polypeptide 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LEFTY1 left-right determination factor 1
LPAR6 lysophosphatidic acid receptor 6
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
PEG3 paternally expressed 3
PFKM phosphofructokinase, muscle
PIR pirin (iron-binding nuclear protein)
PSD3 pleckstrin and Sec7 domain containing 3
PYCARD PYD and CARD domain containing
RGS1 regulator of G-protein signaling 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SESN1 sestrin 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
STC1 stanniocalcin 1
TFF1 trefoil factor 1
TRBC1 T cell receptor beta constant 1
TSPAN5 tetraspanin 5
TYMS thymidylate synthetase
WWP1 WW domain containing E3 ubiquitin protein ligase 1
ZMAT3 zinc finger, matrin-type 3
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AKR1C1 aldo-keto reductase family 1, member C1
ALCAM activated leukocyte cell adhesion molecule
ANXA1 annexin A1
ANXA3 annexin A3
APOD apolipoprotein D
AREG amphiregulin
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
AURKB aurora kinase B
BTBD3 BTB (POZ) domain containing 3
CCNB1 cyclin B1
CCND1 cyclin D1
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CFH complement factor H
CHRDL1 chordin-like 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLU clusterin
COL14A1 collagen, type XIV, alpha 1
COL3A1 collagen, type III, alpha 1
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5A cytochrome b5 type A (microsomal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCLK1 doublecortin-like kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPYSL3 dihydropyrimidinase-like 3
DST dystonin
EAPP E2F-associated phosphoprotein
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPCAM epithelial cell adhesion molecule
FABP4 fatty acid binding protein 4, adipocyte
FGFR2 fibroblast growth factor receptor 2
FSTL1 follistatin-like 1
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
IL1R1 interleukin 1 receptor, type I
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
KIF14 kinesin family member 14
KIF23 kinesin family member 23
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LUM lumican
MAB21L2 mab-21-like 2 (C. elegans)
MAP1B microtubule-associated protein 1B
MAP7 microtubule-associated protein 7
MFAP5 microfibrillar associated protein 5
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
NDC80 NDC80 kinetochore complex component
NFIB nuclear factor I/B
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NTS neurotensin
PAPD7 PAP associated domain containing 7
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDGFD platelet derived growth factor D
PIP prolactin-induced protein
PMP22 peripheral myelin protein 22
PRELP proline/arginine-rich end leucine-rich repeat protein
PRPF4 pre-mRNA processing factor 4
PTRF polymerase I and transcript release factor
SCGB2A2 secretoglobin, family 2A, member 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
VAT1 vesicle amine transport 1