BRD-K21680192_mitoxantrone_MCF10A_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-K21680192_mitoxantrone_MCF10A_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACP5 acid phosphatase 5, tartrate resistant
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA4 annexin A4
APOC1 apolipoprotein C-I
APOE apolipoprotein E
AQP3 aquaporin 3 (Gill blood group)
BEX1 brain expressed, X-linked 1
BTG2 BTG family, member 2
CCL20 chemokine (C-C motif) ligand 20
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CFB complement factor B
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLCA2 chloride channel accessory 2
CSTA cystatin A (stefin A)
CTSE cathepsin E
DDB2 damage-specific DNA binding protein 2, 48kDa
DUSP10 dual specificity phosphatase 10
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FGFR3 fibroblast growth factor receptor 3
GDF15 growth differentiation factor 15
GM2A GM2 ganglioside activator
GPER1 G protein-coupled estrogen receptor 1
GRB7 growth factor receptor-bound protein 7
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
IER5 immediate early response 5
JCHAIN joining chain of multimeric IgA and IgM
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT6A keratin 6A, type II
KYNU kynureninase
LMO2 LIM domain only 2 (rhombotin-like 1)
LY96 lymphocyte antigen 96
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN2B1 mannosidase, alpha, class 2B, member 1
MDK midkine (neurite growth-promoting factor 2)
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MUC4 mucin 4, cell surface associated
OSBPL3 oxysterol binding protein-like 3
PLK2 polo-like kinase 2
PLXNB2 plexin B2
PSAP prosaposin
RPS27L ribosomal protein S27-like
S100A4 S100 calcium binding protein A4
SDC1 syndecan 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SLPI secretory leukocyte peptidase inhibitor
SPRED2 sprouty-related, EVH1 domain containing 2
STC1 stanniocalcin 1
STS steroid sulfatase (microsomal), isozyme S
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP53I3 tumor protein p53 inducible protein 3
TRIM22 tripartite motif containing 22
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ADIPOQ adiponectin, C1Q and collagen domain containing
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA3 annexin A3
ANXA5 annexin A5
ANXA6 annexin A6
ATF1 activating transcription factor 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BTBD3 BTB (POZ) domain containing 3
C6ORF62 chromosome 6 open reading frame 62
CCNE2 cyclin E2
CD9 CD9 molecule
CDC42 cell division cycle 42
CDCA4 cell division cycle associated 4
CFD complement factor D (adipsin)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL5A2 collagen, type V, alpha 2
CREB1 cAMP responsive element binding protein 1
CTBP2 C-terminal binding protein 2
CTSG cathepsin G
DPYSL3 dihydropyrimidinase-like 3
EFNB2 ephrin-B2
EGR1 early growth response 1
EIF5 eukaryotic translation initiation factor 5
ELANE elastase, neutrophil expressed
FHL1 four and a half LIM domains 1
FST follistatin
FSTL1 follistatin-like 1
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GAS1 growth arrest-specific 1
GOLM1 golgi membrane protein 1
HIST1H4C histone cluster 1, H4c
IER2 immediate early response 2
ITM2A integral membrane protein 2A
KRT18 keratin 18, type I
LBR lamin B receptor
LPL lipoprotein lipase
MBP myelin basic protein
NFIB nuclear factor I/B
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PDLIM3 PDZ and LIM domain 3
PHACTR2 phosphatase and actin regulator 2
PHGDH phosphoglycerate dehydrogenase
PLIN1 perilipin 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRPF4 pre-mRNA processing factor 4
RHOBTB3 Rho-related BTB domain containing 3
SACS sacsin molecular chaperone
SYNM synemin, intermediate filament protein
TARP TCR gamma alternate reading frame protein
TGFB3 transforming growth factor, beta 3
TMPO thymopoietin
TMSB15A thymosin beta 15a
TUBB3 tubulin, beta 3 class III
TUBB6 tubulin, beta 6 class V
USP1 ubiquitin specific peptidase 1
VIM vimentin
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
WWTR1 WW domain containing transcription regulator 1