BRD-K21680192_mitoxantrone_LNCAP_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K21680192_mitoxantrone_LNCAP_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCK3 aarF domain containing kinase 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AK1 adenylate kinase 1
ANKRD10 ankyrin repeat domain 10
ATF5 activating transcription factor 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
EIF5A eukaryotic translation initiation factor 5A
FAS Fas cell surface death receptor
FBLN1 fibulin 1
G0S2 G0/G1 switch 2
GSTP1 glutathione S-transferase pi 1
LRRC16A leucine rich repeat containing 16A
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MXRA5 matrix-remodelling associated 5
NOTCH1 notch 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RPS27L ribosomal protein S27-like
S100A9 S100 calcium binding protein A9
SFRP4 secreted frizzled-related protein 4
STS steroid sulfatase (microsomal), isozyme S
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADM adrenomedullin
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AMD1 adenosylmethionine decarboxylase 1
ANXA1 annexin A1
ARID5B AT rich interactive domain 5B (MRF1-like)
BHLHE40 basic helix-loop-helix family, member e40
CCNF cyclin F
CLDN3 claudin 3
CTSZ cathepsin Z
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
EDN3 endothelin 3
EFNA1 ephrin-A1
GATA2 GATA binding protein 2
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
IGLJ3 immunoglobulin lambda joining 3
JCHAIN joining chain of multimeric IgA and IgM
KIF20A kinesin family member 20A
MAP7 microtubule-associated protein 7
MAT2A methionine adenosyltransferase II, alpha
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPTX2 neuronal pentraxin II
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG10 paternally expressed 10
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PON3 paraoxonase 3
PRR15L proline rich 15-like
PSRC1 proline/serine-rich coiled-coil 1
PTX3 pentraxin 3, long
RND3 Rho family GTPase 3
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
STC2 stanniocalcin 2
TNS3 tensin 3
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TUBA4A tubulin, alpha 4a
UGCG UDP-glucose ceramide glucosyltransferase