BRD-K21680192_mitoxantrone_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

318 genes differentially expressed following the BRD-K21680192_mitoxantrone_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD3 abhydrolase domain containing 3
ACAA1 acetyl-CoA acyltransferase 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD36B ankyrin repeat domain 36B
ANXA5 annexin A5
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
ATF5 activating transcription factor 5
BAG3 BCL2-associated athanogene 3
BCL3 B-cell CLL/lymphoma 3
BST2 bone marrow stromal cell antigen 2
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C1R complement component 1, r subcomponent
CAPN2 calpain 2, (m/II) large subunit
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNE2 cyclin E2
CD163 CD163 molecule
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
CLEC2B C-type lectin domain family 2, member B
CLTB clathrin, light chain B
CLU clusterin
CORO1A coronin, actin binding protein, 1A
CRIP1 cysteine-rich protein 1 (intestinal)
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTSL cathepsin L
CTSV cathepsin V
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYR61 cysteine-rich, angiogenic inducer, 61
DCLK1 doublecortin-like kinase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DYNLT3 dynein, light chain, Tctex-type 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENO2 enolase 2 (gamma, neuronal)
ETV5 ets variant 5
FAM129A family with sequence similarity 129, member A
FAM134B family with sequence similarity 134, member B
FBXO21 F-box protein 21
FGF13 fibroblast growth factor 13
FGFR3 fibroblast growth factor receptor 3
FUCA1 fucosidase, alpha-L- 1, tissue
FZD6 frizzled class receptor 6
GCHFR GTP cyclohydrolase I feedback regulator
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
HDGFRP3 hepatoma-derived growth factor, related protein 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGN3 high mobility group nucleosomal binding domain 3
HSPA2 heat shock 70kDa protein 2
HSPB1 heat shock 27kDa protein 1
HSPB11 heat shock protein family B (small), member 11
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
KDM5D lysine (K)-specific demethylase 5D
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
LBH limb bud and heart development
LHX2 LIM homeobox 2
LOX lysyl oxidase
LYPD1 LY6/PLAUR domain containing 1
MAN1C1 mannosidase, alpha, class 1C, member 1
MDK midkine (neurite growth-promoting factor 2)
MICB MHC class I polypeptide-related sequence B
MIR22HG MIR22 host gene
MOXD1 monooxygenase, DBH-like 1
MSH6 mutS homolog 6
MSLN mesothelin
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
MYLK myosin light chain kinase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NPTX2 neuronal pentraxin II
NPY1R neuropeptide Y receptor Y1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OSBPL1A oxysterol binding protein-like 1A
OSBPL8 oxysterol binding protein-like 8
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PER2 period circadian clock 2
PHYH phytanoyl-CoA 2-hydroxylase
PI3 peptidase inhibitor 3, skin-derived
PINK1 PTEN induced putative kinase 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPL periplakin
PRKCI protein kinase C, iota
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PRSS23 protease, serine, 23
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RBP1 retinol binding protein 1, cellular
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RECQL RecQ helicase-like
RFC2 replication factor C (activator 1) 2, 40kDa
RNF167 ring finger protein 167
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
S100A13 S100 calcium binding protein A13
S100A2 S100 calcium binding protein A2
SDC4 syndecan 4
SEPT10 septin 10
SGK1 serum/glucocorticoid regulated kinase 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SOD2 superoxide dismutase 2, mitochondrial
SORBS3 sorbin and SH3 domain containing 3
SPAG4 sperm associated antigen 4
SRSF6 serine/arginine-rich splicing factor 6
STXBP2 syntaxin binding protein 2
SYNM synemin, intermediate filament protein
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFA transforming growth factor, alpha
TMEM106C transmembrane protein 106C
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPBG trophoblast glycoprotein
TSC22D3 TSC22 domain family, member 3
TSPAN3 tetraspanin 3
TSPAN4 tetraspanin 4
TUBA1A tubulin, alpha 1a
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UBE2A ubiquitin-conjugating enzyme E2A
UBE2B ubiquitin-conjugating enzyme E2B
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
WDTC1 WD and tetratricopeptide repeats 1
WEE1 WEE1 G2 checkpoint kinase
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACACA acetyl-CoA carboxylase alpha
ACPP acid phosphatase, prostate
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ADK adenosine kinase
AHSP alpha hemoglobin stabilizing protein
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALAS2 5'-aminolevulinate synthase 2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANGPT1 angiopoietin 1
ANXA1 annexin A1
APOD apolipoprotein D
AREG amphiregulin
ASCC3 activating signal cointegrator 1 complex subunit 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATXN1 ataxin 1
AUTS2 autism susceptibility candidate 2
AVEN apoptosis, caspase activation inhibitor
BOP1 block of proliferation 1
BZW2 basic leucine zipper and W2 domains 2
C1QBP complement component 1, q subcomponent binding protein
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CCNB1 cyclin B1
CCND2 cyclin D2
CD200 CD200 molecule
CD58 CD58 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFD complement factor D (adipsin)
CFH complement factor H
CFI complement factor I
CHI3L2 chitinase 3-like 2
CLNS1A chloride channel, nucleotide-sensitive, 1A
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COG5 component of oligomeric golgi complex 5
COMMD10 COMM domain containing 10
CREB3L2 cAMP responsive element binding protein 3-like 2
CRISP3 cysteine-rich secretory protein 3
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL5 chemokine (C-X-C motif) ligand 5
CYB5A cytochrome b5 type A (microsomal)
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEFA4 defensin, alpha 4, corticostatin
DHCR7 7-dehydrocholesterol reductase
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
ELANE elastase, neutrophil expressed
EPRS glutamyl-prolyl-tRNA synthetase
EREG epiregulin
EXOSC4 exosome component 4
FASN fatty acid synthase
FGFR4 fibroblast growth factor receptor 4
FHOD3 formin homology 2 domain containing 3
FKBP5 FK506 binding protein 5
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATAD2A GATA zinc finger domain containing 2A
GMDS GDP-mannose 4,6-dehydratase
GPX2 glutathione peroxidase 2
GYPA glycophorin A (MNS blood group)
HBB hemoglobin, beta
HBD hemoglobin, delta
HDDC2 HD domain containing 2
HEPH hephaestin
HMBS hydroxymethylbilane synthase
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IARS isoleucyl-tRNA synthetase
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INSIG1 insulin induced gene 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA6 integrin, alpha 6
ITM2A integral membrane protein 2A
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LARP1 La ribonucleoprotein domain family, member 1
LBR lamin B receptor
LCN2 lipocalin 2
LEPR leptin receptor
LPAR6 lysophosphatidic acid receptor 6
LTF lactotransferrin
LYPLA1 lysophospholipase I
LYZ lysozyme
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MECOM MDS1 and EVI1 complex locus
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MINA MYC induced nuclear antigen
MLPH melanophilin
MMP7 matrix metallopeptidase 7
MPO myeloperoxidase
MPZL2 myelin protein zero-like 2
MREG melanoregulin
MRPL12 mitochondrial ribosomal protein L12
MRPL24 mitochondrial ribosomal protein L24
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MTA1 metastasis associated 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative)
NES nestin
NFE2 nuclear factor, erythroid 2
NHP2 NHP2 ribonucleoprotein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOP16 NOP16 nucleolar protein
NPM3 nucleophosmin/nucleoplasmin 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OLFM4 olfactomedin 4
OPN3 opsin 3
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PPA1 pyrophosphatase (inorganic) 1
PPARG peroxisome proliferator-activated receptor gamma
PRMT1 protein arginine methyltransferase 1
PROM1 prominin 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PUS7 pseudouridylate synthase 7 (putative)
PYCR1 pyrroline-5-carboxylate reductase 1
RAD23B RAD23 homolog B (S. cerevisiae)
RGCC regulator of cell cycle
RHOBTB3 Rho-related BTB domain containing 3
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
S100P S100 calcium binding protein P
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SRI sorcin
SRM spermidine synthase
SRP72 signal recognition particle 72kDa
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK10 serine/threonine kinase 10
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBI transforming growth factor, beta-induced, 68kDa
TKT transketolase
TLR4 toll-like receptor 4
TM9SF3 transmembrane 9 superfamily member 3
TMEM100 transmembrane protein 100
TMEM47 transmembrane protein 47
TRAP1 TNF receptor-associated protein 1
TSPAN8 tetraspanin 8
UCK2 uridine-cytidine kinase 2
USP3 ubiquitin specific peptidase 3
VCAN versican
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZBTB16 zinc finger and BTB domain containing 16