BRD-K21680192_mitoxantrone_HS578T_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-K21680192_mitoxantrone_HS578T_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
ATF5 activating transcription factor 5
BIRC3 baculoviral IAP repeat containing 3
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CYB5R1 cytochrome b5 reductase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP5 dual specificity phosphatase 5
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBLN1 fibulin 1
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HDAC9 histone deacetylase 9
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDO1 indoleamine 2,3-dioxygenase 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
ITM2C integral membrane protein 2C
KIF5C kinesin family member 5C
KLF4 Kruppel-like factor 4 (gut)
KRT19 keratin 19, type I
LAMA3 laminin, alpha 3
LAMP3 lysosomal-associated membrane protein 3
LEF1 lymphoid enhancer-binding factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCM4 minichromosome maintenance complex component 4
MICB MHC class I polypeptide-related sequence B
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MTCL1 microtubule crosslinking factor 1
MTSS1 metastasis suppressor 1
NEB nebulin
NEFL neurofilament, light polypeptide
PERP PERP, TP53 apoptosis effector
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RCAN1 regulator of calcineurin 1
RFC2 replication factor C (activator 1) 2, 40kDa
RHOB ras homolog family member B
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SNAP25 synaptosomal-associated protein, 25kDa
SOD2 superoxide dismutase 2, mitochondrial
TATDN2 TatD DNase domain containing 2
TGFA transforming growth factor, alpha
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAPPC3 trafficking protein particle complex 3
TRIB2 tribbles pseudokinase 2
TSPAN7 tetraspanin 7
VNN1 vanin 1
XIST X inactive specific transcript (non-protein coding)
ZWINT ZW10 interacting kinetochore protein

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ADK adenosine kinase
AKAP13 A kinase (PRKA) anchor protein 13
ANK2 ankyrin 2, neuronal
ANXA3 annexin A3
ASNS asparagine synthetase (glutamine-hydrolyzing)
AUTS2 autism susceptibility candidate 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CD163 CD163 molecule
CD44 CD44 molecule (Indian blood group)
CENPA centromere protein A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHRDL1 chordin-like 1
CKAP4 cytoskeleton-associated protein 4
CREB3L2 cAMP responsive element binding protein 3-like 2
CTNND1 catenin (cadherin-associated protein), delta 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLK1 delta-like 1 homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA3 EPH receptor A3
FAM171A1 family with sequence similarity 171, member A1
FXYD5 FXYD domain containing ion transport regulator 5
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS1 growth arrest-specific 1
GLS glutaminase
GSTO1 glutathione S-transferase omega 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IRS1 insulin receptor substrate 1
JAM3 junctional adhesion molecule 3
KDM5D lysine (K)-specific demethylase 5D
KIAA1033 KIAA1033
KIF20A kinesin family member 20A
LAPTM5 lysosomal protein transmembrane 5
LIMCH1 LIM and calponin homology domains 1
LMO4 LIM domain only 4
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MEIS2 Meis homeobox 2
MINA MYC induced nuclear antigen
NFIB nuclear factor I/B
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRP1 neuropilin 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPD7 PAP associated domain containing 7
PCDH9 protocadherin 9
PEG3 paternally expressed 3
PLK1 polo-like kinase 1
PLS3 plastin 3
PODXL podocalyxin-like
PPAP2B phosphatidic acid phosphatase type 2B
PSRC1 proline/serine-rich coiled-coil 1
PTN pleiotrophin
PTPRK protein tyrosine phosphatase, receptor type, K
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PXDN peroxidasin
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RUFY3 RUN and FYVE domain containing 3
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SDC2 syndecan 2
SEC63 SEC63 homolog (S. cerevisiae)
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLIT2 slit homolog 2 (Drosophila)
SOBP sine oculis binding protein homolog (Drosophila)
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TCF4 transcription factor 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TGFB3 transforming growth factor, beta 3
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM45A transmembrane protein 45A
TNC tenascin C
WWTR1 WW domain containing transcription regulator 1
ZIC1 Zic family member 1