BRD-K21680192_mitoxantrone_HME1_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

188 genes differentially expressed following the BRD-K21680192_mitoxantrone_HME1_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACAA1 acetyl-CoA acyltransferase 1
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BCHE butyrylcholinesterase
CADM1 cell adhesion molecule 1
CBR3 carbonyl reductase 3
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CCNE2 cyclin E2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD84 CD84 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CFB complement factor B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN10 claudin 10
CLU clusterin
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CST6 cystatin E/M
CTSV cathepsin V
CXCL10 chemokine (C-X-C motif) ligand 10
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEFB1 defensin, beta 1
DSP desmoplakin
EGR2 early growth response 2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM46A family with sequence similarity 46, member A
FBP1 fructose-1,6-bisphosphatase 1
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GCH1 GTP cyclohydrolase 1
GLRX glutaredoxin (thioltransferase)
GPNMB glycoprotein (transmembrane) nmb
GRAMD3 GRAM domain containing 3
GSTM3 glutathione S-transferase mu 3 (brain)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ICAM1 intercellular adhesion molecule 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IL6 interleukin 6
IRF1 interferon regulatory factor 1
JUN jun proto-oncogene
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDM5A lysine (K)-specific demethylase 5A
KLF11 Kruppel-like factor 11
KLHL24 kelch-like family member 24
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LAMP3 lysosomal-associated membrane protein 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCOLN1 mucolipin 1
MICB MHC class I polypeptide-related sequence B
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MYB v-myb avian myeloblastosis viral oncogene homolog
NBPF10 neuroblastoma breakpoint family, member 10
NEU1 sialidase 1 (lysosomal sialidase)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NKTR natural killer cell triggering receptor
NR4A2 nuclear receptor subfamily 4, group A, member 2
OASL 2'-5'-oligoadenylate synthetase-like
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
OSR2 odd-skipped related transciption factor 2
PERP PERP, TP53 apoptosis effector
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLK2 polo-like kinase 2
PLS1 plastin 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCI protein kinase C, iota
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBKS ribokinase
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RGS16 regulator of G-protein signaling 16
RNASET2 ribonuclease T2
RPL37A ribosomal protein L37a
RRAGD Ras-related GTP binding D
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SCD5 stearoyl-CoA desaturase 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC16A6 solute carrier family 16, member 6
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SOX4 SRY (sex determining region Y)-box 4
SPRR2B small proline-rich protein 2B
SRSF11 serine/arginine-rich splicing factor 11
SRSF7 serine/arginine-rich splicing factor 7
STAT1 signal transducer and activator of transcription 1, 91kDa
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFA transforming growth factor, alpha
TKTL1 transketolase-like 1
TLR4 toll-like receptor 4
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ACTN1 actinin, alpha 1
AHNAK AHNAK nucleoprotein
ANXA3 annexin A3
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BIN1 bridging integrator 1
CA2 carbonic anhydrase II
CCNF cyclin F
CENPF centromere protein F, 350/400kDa
COL4A5 collagen, type IV, alpha 5
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL2 dihydropyrimidinase-like 2
ECD ecdysoneless homolog (Drosophila)
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPRS glutamyl-prolyl-tRNA synthetase
FGFR3 fibroblast growth factor receptor 3
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
HMGA2 high mobility group AT-hook 2
IARS isoleucyl-tRNA synthetase
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
ITGA6 integrin, alpha 6
KIF20A kinesin family member 20A
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LOXL2 lysyl oxidase-like 2
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MKI67 marker of proliferation Ki-67
MYOF myoferlin
NCK1 NCK adaptor protein 1
NELL2 NEL-like 2 (chicken)
NME4 NME/NM23 nucleoside diphosphate kinase 4
PAM peptidylglycine alpha-amidating monooxygenase
PDLIM1 PDZ and LIM domain 1
PLK1 polo-like kinase 1
PUF60 poly-U binding splicing factor 60KDa
PYCR1 pyrroline-5-carboxylate reductase 1
RNASE4 ribonuclease, RNase A family, 4
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPT9 septin 9
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SORBS3 sorbin and SH3 domain containing 3
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYPL1 synaptophysin-like 1
TACC2 transforming, acidic coiled-coil containing protein 2
TAGLN2 transgelin 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TPX2 TPX2, microtubule-associated
TSPAN4 tetraspanin 4
TUBB tubulin, beta class I
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
VGLL4 vestigial-like family member 4
ZFP36L2 ZFP36 ring finger protein-like 2