BRD-K21680192_mitoxantrone_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

377 genes differentially expressed following the BRD-K21680192_mitoxantrone_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACACB acetyl-CoA carboxylase beta
ADGRG2 adhesion G protein-coupled receptor G2
ADM adrenomedullin
AIM1 absent in melanoma 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ANKRD28 ankyrin repeat domain 28
ANPEP alanyl (membrane) aminopeptidase
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APOLD1 apolipoprotein L domain containing 1
ARG2 arginase 2
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAG3 BCL2-associated athanogene 3
BANK1 B-cell scaffold protein with ankyrin repeats 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BHLHE41 basic helix-loop-helix family, member e41
BMP7 bone morphogenetic protein 7
BTG2 BTG family, member 2
CAB39 calcium binding protein 39
CADM1 cell adhesion molecule 1
CBR3 carbonyl reductase 3
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCND1 cyclin D1
CCNG2 cyclin G2
CD24 CD24 molecule
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2AIP CDKN2A interacting protein
CGRRF1 cell growth regulator with ring finger domain 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLGN calmegin
CLU clusterin
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL9A3 collagen, type IX, alpha 3
CPVL carboxypeptidase, vitellogenic-like
CRIP1 cysteine-rich protein 1 (intestinal)
CRY1 cryptochrome circadian clock 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DACH1 dachshund family transcription factor 1
DAPK1 death-associated protein kinase 1
DDIT3 DNA-damage-inducible transcript 3
DIABLO diablo, IAP-binding mitochondrial protein
DKK2 dickkopf WNT signaling pathway inhibitor 2
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DPP4 dipeptidyl-peptidase 4
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF5 eukaryotic translation initiation factor 5
EPAS1 endothelial PAS domain protein 1
EXOC1 exocyst complex component 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
EZR ezrin
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM46A family with sequence similarity 46, member A
FGF13 fibroblast growth factor 13
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GPX3 glutathione peroxidase 3
H1F0 H1 histone family, member 0
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HNMT histamine N-methyltransferase
HSPB8 heat shock 22kDa protein 8
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IER2 immediate early response 2
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUND jun D proto-oncogene
KAT6B K(lysine) acetyltransferase 6B
KDM5B lysine (K)-specific demethylase 5B
KDM6B lysine (K)-specific demethylase 6B
KIAA0907 KIAA0907
KLF6 Kruppel-like factor 6
LINC00341 long intergenic non-protein coding RNA 341
LIPG lipase, endothelial
LMNA lamin A/C
LMO3 LIM domain only 3 (rhombotin-like 2)
LPIN1 lipin 1
LPL lipoprotein lipase
LSR lipolysis stimulated lipoprotein receptor
LYN LYN proto-oncogene, Src family tyrosine kinase
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MT2A metallothionein 2A
MX1 MX dynamin-like GTPase 1
MYH11 myosin, heavy chain 11, smooth muscle
MYO6 myosin VI
NDP Norrie disease (pseudoglioma)
NEFH neurofilament, heavy polypeptide
NMB neuromedin B
NOV nephroblastoma overexpressed
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OASL 2'-5'-oligoadenylate synthetase-like
OSER1 oxidative stress responsive serine-rich 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAX8 paired box 8
PDLIM4 PDZ and LIM domain 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PKP1 plakophilin 1
PLAU plasminogen activator, urokinase
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLN phospholamban
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPIF peptidylprolyl isomerase F
PPL periplakin
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PROM1 prominin 1
PSAP prosaposin
PTN pleiotrophin
PXMP2 peroxisomal membrane protein 2, 22kDa
RAP1GAP RAP1 GTPase activating protein
RBKS ribokinase
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS5 regulator of G-protein signaling 5
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RNF114 ring finger protein 114
RNF167 ring finger protein 167
S100A2 S100 calcium binding protein A2
SC5D sterol-C5-desaturase
SDC4 syndecan 4
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SMAD3 SMAD family member 3
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX11 SRY (sex determining region Y)-box 11
SOX9 SRY (sex determining region Y)-box 9
SPAG4 sperm associated antigen 4
SPRR2B small proline-rich protein 2B
TBX3 T-box 3
TENM1 teneurin transmembrane protein 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFA transforming growth factor, alpha
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TJP2 tight junction protein 2
TKTL1 transketolase-like 1
TM4SF1 transmembrane 4 L six family member 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOP1 topoisomerase (DNA) I
TP53 tumor protein p53
TRA2B transformer 2 beta homolog (Drosophila)
TSC22D2 TSC22 domain family, member 2
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UBE3B ubiquitin protein ligase E3B
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WEE1 WEE1 G2 checkpoint kinase
WSB1 WD repeat and SOCS box containing 1
YBX3 Y box binding protein 3
YTHDC1 YTH domain containing 1
ZEB1 zinc finger E-box binding homeobox 1
ZFP36 ZFP36 ring finger protein
ZMYM5 zinc finger, MYM-type 5
ZNF140 zinc finger protein 140
ZNF274 zinc finger protein 274
ZNF430 zinc finger protein 430
ZNF432 zinc finger protein 432
ZNF91 zinc finger protein 91
ZNF93 zinc finger protein 93

decreased expression

Symbol Name
ABR active BCR-related
ADD3 adducin 3 (gamma)
AK4 adenylate kinase 4
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARHGAP32 Rho GTPase activating protein 32
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ARSE arylsulfatase E (chondrodysplasia punctata 1)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
B3GNT1
BCHE butyrylcholinesterase
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C3 complement component 3
C4BPA complement component 4 binding protein, alpha
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CALD1 caldesmon 1
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CBS cystathionine-beta-synthase
CCNA2 cyclin A2
CCNF cyclin F
CD14 CD14 molecule
CD200 CD200 molecule
CENPF centromere protein F, 350/400kDa
CERK ceramide kinase
CFH complement factor H
CHGB chromogranin B
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLNS1A chloride channel, nucleotide-sensitive, 1A
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL4A5 collagen, type IV, alpha 5
CP ceruloplasmin (ferroxidase)
CPB1 carboxypeptidase B1 (tissue)
CRTAP cartilage associated protein
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DCT dopachrome tautomerase
DDHD2 DDHD domain containing 2
DICER1 dicer 1, ribonuclease type III
DLD dihydrolipoamide dehydrogenase
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
ENOSF1 enolase superfamily member 1
EPRS glutamyl-prolyl-tRNA synthetase
ESR1 estrogen receptor 1
F12 coagulation factor XII (Hageman factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM162A family with sequence similarity 162, member A
FCHSD2 FCH and double SH3 domains 2
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FTO fat mass and obesity associated
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GJA1 gap junction protein, alpha 1, 43kDa
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GRIA2 glutamate receptor, ionotropic, AMPA 2
HBB hemoglobin, beta
HBE1 hemoglobin, epsilon 1
HP haptoglobin
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
KCTD12 potassium channel tetramerization domain containing 12
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF20A kinesin family member 20A
KRT19 keratin 19, type I
LAMB1 laminin, beta 1
LCN2 lipocalin 2
LMNB1 lamin B1
LYPLA1 lysophospholipase I
MAGEA3 melanoma antigen family A3
MFAP3L microfibrillar-associated protein 3-like
MLANA melan-A
MYH10 myosin, heavy chain 10, non-muscle
NAMPT nicotinamide phosphoribosyltransferase
NIT2 nitrilase family, member 2
NLRP2 NLR family, pyrin domain containing 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NNMT nicotinamide N-methyltransferase
NRIP1 nuclear receptor interacting protein 1
OLFM1 olfactomedin 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PBK PDZ binding kinase
PCSK1 proprotein convertase subtilisin/kexin type 1
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PID1 phosphotyrosine interaction domain containing 1
PIR pirin (iron-binding nuclear protein)
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
PODXL podocalyxin-like
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGIS prostaglandin I2 (prostacyclin) synthase
PUS7 pseudouridylate synthase 7 (putative)
PYCR1 pyrroline-5-carboxylate reductase 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS4 regulator of G-protein signaling 4
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPHS1 selenophosphate synthetase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMYD2 SET and MYND domain containing 2
SNX10 sorting nexin 10
SPDEF SAM pointed domain containing ETS transcription factor
SPINK1 serine peptidase inhibitor, Kazal type 1
SRGN serglycin
STEAP1 six transmembrane epithelial antigen of the prostate 1
SULF1 sulfatase 1
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TF transferrin
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TKT transketolase
TM9SF3 transmembrane 9 superfamily member 3
TMEM109 transmembrane protein 109
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TNS3 tensin 3
TRAP1 TNF receptor-associated protein 1
TSPAN13 tetraspanin 13
TUBB tubulin, beta class I
TUSC3 tumor suppressor candidate 3
UCK2 uridine-cytidine kinase 2
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
VCAN versican
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)
XPOT exportin, tRNA
ZNF652 zinc finger protein 652