BRD-K21680192_mitoxantrone_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

405 genes differentially expressed following the BRD-K21680192_mitoxantrone_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD4 abhydrolase domain containing 4
ACSL5 acyl-CoA synthetase long-chain family member 5
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAMDEC1 ADAM-like, decysin 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AIM1 absent in melanoma 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANGPTL2 angiopoietin-like 2
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
APLP2 amyloid beta (A4) precursor-like protein 2
APOC1 apolipoprotein C-I
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
BLCAP bladder cancer associated protein
BLNK B-cell linker
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C6ORF62 chromosome 6 open reading frame 62
CAB39 calcium binding protein 39
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBR3 carbonyl reductase 3
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL4 chemokine (C-C motif) ligand 4
CCND2 cyclin D2
CCND3 cyclin D3
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CELF2 CUGBP, Elav-like family member 2
CES1 carboxylesterase 1
CES2 carboxylesterase 2
CFB complement factor B
CLCA2 chloride channel accessory 2
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
COL3A1 collagen, type III, alpha 1
COL4A6 collagen, type IV, alpha 6
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CSRNP2 cysteine-serine-rich nuclear protein 2
CSTA cystatin A (stefin A)
CTSK cathepsin K
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYB561 cytochrome b561
DACH1 dachshund family transcription factor 1
DCLK1 doublecortin-like kinase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDR1 discoidin domain receptor tyrosine kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DGKA diacylglycerol kinase, alpha 80kDa
DSP desmoplakin
DST dystonin
DTX4 deltex 4, E3 ubiquitin ligase
DUSP14 dual specificity phosphatase 14
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGR2 early growth response 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV5 ets variant 5
FABP4 fatty acid binding protein 4, adipocyte
FAM134A family with sequence similarity 134, member A
FAM46A family with sequence similarity 46, member A
FAS Fas cell surface death receptor
FBP1 fructose-1,6-bisphosphatase 1
FDXR ferredoxin reductase
FOXO4 forkhead box O4
FXYD3 FXYD domain containing ion transport regulator 3
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GADD45A growth arrest and DNA-damage-inducible, alpha
GALE UDP-galactose-4-epimerase
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GPC1 glypican 1
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GSDMB gasdermin B
GSTT1 glutathione S-transferase theta 1
H2BFS H2B histone family, member S (pseudogene)
HCAR3 hydroxycarboxylic acid receptor 3
HECA headcase homolog (Drosophila)
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HNMT histamine N-methyltransferase
HOXD1 homeobox D1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IGF1R insulin-like growth factor 1 receptor
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHM immunoglobulin heavy constant mu
IL13RA1 interleukin 13 receptor, alpha 1
IL13RA2 interleukin 13 receptor, alpha 2
IL1B interleukin 1, beta
INHBB inhibin, beta B
INPP1 inositol polyphosphate-1-phosphatase
IRF1 interferon regulatory factor 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITGB4 integrin, beta 4
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
LGALS3 lectin, galactoside-binding, soluble, 3
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LYPD3 LY6/PLAUR domain containing 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MCOLN1 mucolipin 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMP12 matrix metallopeptidase 12
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MTSS1 metastasis suppressor 1
MTUS1 microtubule associated tumor suppressor 1
N4BP2L1 NEDD4 binding protein 2-like 1
NCF2 neutrophil cytosolic factor 2
NDP Norrie disease (pseudoglioma)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
OSR2 odd-skipped related transciption factor 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCDH17 protocadherin 17
PDE2A phosphodiesterase 2A, cGMP-stimulated
PEG3 paternally expressed 3
PER2 period circadian clock 2
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLVAP plasmalemma vesicle associated protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPL periplakin
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRNP prion protein
PSD3 pleckstrin and Sec7 domain containing 3
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
PTN pleiotrophin
PTPRE protein tyrosine phosphatase, receptor type, E
RAD51C RAD51 paralog C
RALGDS ral guanine nucleotide dissociation stimulator
RAP1GAP RAP1 GTPase activating protein
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RB1CC1 RB1-inducible coiled-coil 1
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RSRP1 arginine/serine-rich protein 1
RUNX3 runt-related transcription factor 3
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SEPP1 selenoprotein P, plasma, 1
SEPT4 septin 4
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SESN1 sestrin 1
SFN stratifin
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SP110 SP110 nuclear body protein
SPARCL1 SPARC-like 1 (hevin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
ST18 suppression of tumorigenicity 18, zinc finger
STAT1 signal transducer and activator of transcription 1, 91kDa
STOM stomatin
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFA transforming growth factor, alpha
TGIF1 TGFB-induced factor homeobox 1
THAP10 THAP domain containing 10
THBD thrombomodulin
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMP1 TIMP metallopeptidase inhibitor 1
TLR4 toll-like receptor 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM30B transmembrane protein 30B
TOB1 transducer of ERBB2, 1
TP53I3 tumor protein p53 inducible protein 3
TP63 tumor protein p63
TRAF3IP2 TRAF3 interacting protein 2
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TSPYL2 TSPY-like 2
TWIST1 twist family bHLH transcription factor 1
TXNL4B thioredoxin-like 4B
UBE3B ubiquitin protein ligase E3B
VSNL1 visinin-like 1
VWA5A von Willebrand factor A domain containing 5A
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AHNAK AHNAK nucleoprotein
AK4 adenylate kinase 4
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ANXA1 annexin A1
ANXA6 annexin A6
ANXA7 annexin A7
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AURKA aurora kinase A
BICC1 BicC family RNA binding protein 1
BIN1 bridging integrator 1
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNF cyclin F
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP170 centrosomal protein 170kDa
CNN3 calponin 3, acidic
COL5A1 collagen, type V, alpha 1
COL9A3 collagen, type IX, alpha 3
CSTB cystatin B (stefin B)
CUX1 cut-like homeobox 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDHD2 DDHD domain containing 2
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNM1 dynamin 1
EGF epidermal growth factor
EIF5A eukaryotic translation initiation factor 5A
ELAVL1 ELAV like RNA binding protein 1
ENO1 enolase 1, (alpha)
EPHB2 EPH receptor B2
EPRS glutamyl-prolyl-tRNA synthetase
EVL Enah/Vasp-like
FABP1 fatty acid binding protein 1, liver
FADS1 fatty acid desaturase 1
FAM171A1 family with sequence similarity 171, member A1
FLNB filamin B, beta
FN1 fibronectin 1
FSTL1 follistatin-like 1
FXYD2 FXYD domain containing ion transport regulator 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLDC glycine dehydrogenase (decarboxylating)
GLIPR1 GLI pathogenesis-related 1
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GRB14 growth factor receptor-bound protein 14
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXA10 homeobox A10
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IL6ST interleukin 6 signal transducer
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG1 insulin induced gene 1
ITGB1BP1 integrin beta 1 binding protein 1
JCHAIN joining chain of multimeric IgA and IgM
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0368 KIAA0368
KIF23 kinesin family member 23
KLF6 Kruppel-like factor 6
KNG1 kininogen 1
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LMNB1 lamin B1
LOX lysyl oxidase
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
MINA MYC induced nuclear antigen
MKI67 marker of proliferation Ki-67
MOK MOK protein kinase
MRPL12 mitochondrial ribosomal protein L12
NAP1L1 nucleosome assembly protein 1-like 1
NEK7 NIMA-related kinase 7
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F2 nuclear receptor subfamily 2, group F, member 2
PAH phenylalanine hydroxylase
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAPOLA poly(A) polymerase alpha
PAX8 paired box 8
PBK PDZ binding kinase
PDLIM2 PDZ and LIM domain 2 (mystique)
PDLIM5 PDZ and LIM domain 5
PDZK1 PDZ domain containing 1
PDZK1IP1 PDZK1 interacting protein 1
PEBP1 phosphatidylethanolamine binding protein 1
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLK1 polo-like kinase 1
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PSPH phosphoserine phosphatase
PYCR1 pyrroline-5-carboxylate reductase 1
QPRT quinolinate phosphoribosyltransferase
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBPMS RNA binding protein with multiple splicing
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RGS4 regulator of G-protein signaling 4
RPL22 ribosomal protein L22
RTN3 reticulon 3
SEPT11 septin 11
SFRP1 secreted frizzled-related protein 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLIT2 slit homolog 2 (Drosophila)
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SNX6 sorting nexin 6
SORD sorbitol dehydrogenase
SPON1 spondin 1, extracellular matrix protein
SRP72 signal recognition particle 72kDa
SRSF3 serine/arginine-rich splicing factor 3
SUMO3 small ubiquitin-like modifier 3
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBC1D4 TBC1 domain family, member 4
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TM9SF3 transmembrane 9 superfamily member 3
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRAPPC3 trafficking protein particle complex 3
TUBB tubulin, beta class I
U2AF1 U2 small nuclear RNA auxiliary factor 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase
VCAM1 vascular cell adhesion molecule 1
VCAN versican
VCL vinculin
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
XPOT exportin, tRNA