BRD-K21680192_mitoxantrone_BT20_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

96 genes differentially expressed following the BRD-K21680192_mitoxantrone_BT20_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
APOA1 apolipoprotein A-I
BHLHE41 basic helix-loop-helix family, member e41
CCND2 cyclin D2
CD36 CD36 molecule (thrombospondin receptor)
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CLIC5 chloride intracellular channel 5
CRYAB crystallin, alpha B
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DUSP3 dual specificity phosphatase 3
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
HBB hemoglobin, beta
HOXC6 homeobox C6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHM immunoglobulin heavy constant mu
IL6 interleukin 6
ITM2C integral membrane protein 2C
JCHAIN joining chain of multimeric IgA and IgM
KRT81 keratin 81, type II
MAMLD1 mastermind-like domain containing 1
NT5E 5'-nucleotidase, ecto (CD73)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
POU2AF1 POU class 2 associating factor 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RGS2 regulator of G-protein signaling 2
RRAGD Ras-related GTP binding D
RRM2 ribonucleotide reductase M2
S100A4 S100 calcium binding protein A4
SATB2 SATB homeobox 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SERINC5 serine incorporator 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SYT1 synaptotagmin I
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNC tenascin C
TPD52L1 tumor protein D52-like 1
VAV3 vav 3 guanine nucleotide exchange factor
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
ACP5 acid phosphatase 5, tartrate resistant
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AK4 adenylate kinase 4
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AQP1 aquaporin 1 (Colton blood group)
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
C3ORF14 chromosome 3 open reading frame 14
CPVL carboxypeptidase, vitellogenic-like
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DACH1 dachshund family transcription factor 1
EIF5A eukaryotic translation initiation factor 5A
EPS8 epidermal growth factor receptor pathway substrate 8
FAM129A family with sequence similarity 129, member A
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FOLR1 folate receptor 1 (adult)
GPRC5B G protein-coupled receptor, class C, group 5, member B
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H2BC histone cluster 1, H2bc
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
KLF7 Kruppel-like factor 7 (ubiquitous)
KRT17 keratin 17, type I
LAMP2 lysosomal-associated membrane protein 2
LMO3 LIM domain only 3 (rhombotin-like 2)
MET MET proto-oncogene, receptor tyrosine kinase
MTUS1 microtubule associated tumor suppressor 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
RBP1 retinol binding protein 1, cellular
RNF167 ring finger protein 167
RUFY3 RUN and FYVE domain containing 3
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SAT1 spermidine/spermine N1-acetyltransferase 1
SHB Src homology 2 domain containing adaptor protein B
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN2 transgelin 2
TARP TCR gamma alternate reading frame protein
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TKT transketolase
WBP5 WW domain binding protein 5
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF721 zinc finger protein 721