BRD-K21680192_mitoxantrone_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

310 genes differentially expressed following the BRD-K21680192_mitoxantrone_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRF5 adhesion G protein-coupled receptor F5
APOC1 apolipoprotein C-I
AQP3 aquaporin 3 (Gill blood group)
ARG1 arginase 1
ARG2 arginase 2
ARHGAP29 Rho GTPase activating protein 29
ATF3 activating transcription factor 3
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BEX1 brain expressed, X-linked 1
BLNK B-cell linker
BTBD3 BTB (POZ) domain containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
C1QB complement component 1, q subcomponent, B chain
C3ORF14 chromosome 3 open reading frame 14
C5AR1 complement component 5a receptor 1
C6ORF48 chromosome 6 open reading frame 48
C8ORF4 chromosome 8 open reading frame 4
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCL8 chemokine (C-C motif) ligand 8
CCNE2 cyclin E2
CCNL1 cyclin L1
CD163 CD163 molecule
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHIC2 cysteine-rich hydrophobic domain 2
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CLGN calmegin
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CPM carboxypeptidase M
CREM cAMP responsive element modulator
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DCLK1 doublecortin-like kinase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
DUSP2 dual specificity phosphatase 2
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR3 early growth response 3
EMX2 empty spiracles homeobox 2
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FLG filaggrin
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FST follistatin
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
H3F3B H3 histone, family 3B (H3.3B)
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
ICAM1 intercellular adhesion molecule 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP1 insulin-like growth factor binding protein 1
IL6 interleukin 6
INHBB inhibin, beta B
IQCG IQ motif containing G
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KRT5 keratin 5, type II
LEFTY2 left-right determination factor 2
LGMN legumain
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MERTK MER proto-oncogene, tyrosine kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOAP1 modulator of apoptosis 1
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MSR1 macrophage scavenger receptor 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEU1 sialidase 1 (lysosomal sialidase)
NPTX2 neuronal pentraxin II
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPR1 nuclear protein, transcriptional regulator, 1
OPHN1 oligophrenin 1
PDHX pyruvate dehydrogenase complex, component X
PELI1 pellino E3 ubiquitin protein ligase 1
PLTP phospholipid transfer protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSD3 pleckstrin and Sec7 domain containing 3
PSMC3IP PSMC3 interacting protein
PTX3 pentraxin 3, long
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBKS ribokinase
RCAN1 regulator of calcineurin 1
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRAGD Ras-related GTP binding D
S100A1 S100 calcium binding protein A1
S100A13 S100 calcium binding protein A13
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCD5 stearoyl-CoA desaturase 5
SCGB2A1 secretoglobin, family 2A, member 1
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC43A3 solute carrier family 43, member 3
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SOD2 superoxide dismutase 2, mitochondrial
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRP54 signal recognition particle 54kDa
SRPR signal recognition particle receptor (docking protein)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STK38L serine/threonine kinase 38 like
STOM stomatin
STX12 syntaxin 12
TBX3 T-box 3
TCF4 transcription factor 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TKTL1 transketolase-like 1
TMEM45A transmembrane protein 45A
TMEM5 transmembrane protein 5
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
TSPAN3 tetraspanin 3
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UBL3 ubiquitin-like 3
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VSIG4 V-set and immunoglobulin domain containing 4
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABR active BCR-related
ADAM10 ADAM metallopeptidase domain 10
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANPEP alanyl (membrane) aminopeptidase
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BLVRA biliverdin reductase A
BRD7 bromodomain containing 7
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CAV2 caveolin 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDH3 cadherin 3, type 1, P-cadherin (placental)
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CPNE1 copine I
CRABP2 cellular retinoic acid binding protein 2
CXCL5 chemokine (C-X-C motif) ligand 5
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DENND1B DENN/MADD domain containing 1B
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOCK10 dedicator of cytokinesis 10
DUSP3 dual specificity phosphatase 3
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FASN fatty acid synthase
FGFR2 fibroblast growth factor receptor 2
FHOD1 formin homology 2 domain containing 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLR1 folate receptor 1 (adult)
FTO fat mass and obesity associated
GATA3 GATA binding protein 3
GOLM1 golgi membrane protein 1
GREM1 gremlin 1, DAN family BMP antagonist
GTSE1 G-2 and S-phase expressed 1
HN1L hematological and neurological expressed 1-like
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IGFBP6 insulin-like growth factor binding protein 6
IGFBP7 insulin-like growth factor binding protein 7
IGKV1-5 immunoglobulin kappa variable 1-5
IVNS1ABP influenza virus NS1A binding protein
JCHAIN joining chain of multimeric IgA and IgM
KIAA0368 KIAA0368
KIF14 kinesin family member 14
KLK11 kallikrein-related peptidase 11
KRT19 keratin 19, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPL lipoprotein lipase
LPP LIM domain containing preferred translocation partner in lipoma
LTF lactotransferrin
LY75 lymphocyte antigen 75
MALL mal, T-cell differentiation protein-like
MAPK13 mitogen-activated protein kinase 13
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MKI67 marker of proliferation Ki-67
MKL2 MKL/myocardin-like 2
MRPL12 mitochondrial ribosomal protein L12
MRPL15 mitochondrial ribosomal protein L15
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYOF myoferlin
NCK1 NCK adaptor protein 1
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME3 NME/NM23 nucleoside diphosphate kinase 3
NME4 NME/NM23 nucleoside diphosphate kinase 4
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
PAM peptidylglycine alpha-amidating monooxygenase
PDZK1IP1 PDZK1 interacting protein 1
PFKP phosphofructokinase, platelet
PIP prolactin-induced protein
PLCB4 phospholipase C, beta 4
PLK1 polo-like kinase 1
PODXL podocalyxin-like
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
PROM1 prominin 1
PSRC1 proline/serine-rich coiled-coil 1
RAP2A RAP2A, member of RAS oncogene family
RBM47 RNA binding motif protein 47
RGS10 regulator of G-protein signaling 10
SEPHS1 selenophosphate synthetase 1
SEPT9 septin 9
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLPI secretory leukocyte peptidase inhibitor
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRI sorcin
TFPI2 tissue factor pathway inhibitor 2
TKT transketolase
TM9SF3 transmembrane 9 superfamily member 3
TNS3 tensin 3
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRAK2 trafficking protein, kinesin binding 2
TSKU tsukushi, small leucine rich proteoglycan
VCAN versican
VDAC1 voltage-dependent anion channel 1
WFDC1 WAP four-disulfide core domain 1
ZFP36L1 ZFP36 ring finger protein-like 1