BRD-K21165668_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

60 genes differentially expressed following the BRD-K21165668_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
CHGB chromogranin B
COLEC12 collectin sub-family member 12
CPA3 carboxypeptidase A3 (mast cell)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DPP4 dipeptidyl-peptidase 4
EZR ezrin
FHL1 four and a half LIM domains 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFI27 interferon, alpha-inducible protein 27
IQGAP1 IQ motif containing GTPase activating protein 1
MAP7 microtubule-associated protein 7
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
OLFM4 olfactomedin 4
PERP PERP, TP53 apoptosis effector
PKP2 plakophilin 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLVAP plasmalemma vesicle associated protein
RCAN2 regulator of calcineurin 2
RGS16 regulator of G-protein signaling 16
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STC1 stanniocalcin 1
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
VIM vimentin

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ARMCX6 armadillo repeat containing, X-linked 6
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CX3CR1 chemokine (C-X3-C motif) receptor 1
EAPP E2F-associated phosphoprotein
GGCX gamma-glutamyl carboxylase
HLTF helicase-like transcription factor
HSPB8 heat shock 22kDa protein 8
KIF2C kinesin family member 2C
NOLC1 nucleolar and coiled-body phosphoprotein 1
NQO1 NAD(P)H dehydrogenase, quinone 1
PARP2 poly (ADP-ribose) polymerase 2
PIR pirin (iron-binding nuclear protein)
PLAC8 placenta-specific 8
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPIG peptidylprolyl isomerase G (cyclophilin G)
PRKCD protein kinase C, delta
SEPW1 selenoprotein W, 1
SNRPE small nuclear ribonucleoprotein polypeptide E
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TOP2A topoisomerase (DNA) II alpha 170kDa