BRD-K21064560_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

139 genes differentially expressed following the BRD-K21064560_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ACSL1 acyl-CoA synthetase long-chain family member 1
ADD3 adducin 3 (gamma)
ADM adrenomedullin
AK4 adenylate kinase 4
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BHLHE41 basic helix-loop-helix family, member e41
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CASP3 caspase 3, apoptosis-related cysteine peptidase
CD38 CD38 molecule
CD58 CD58 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CNIH1 cornichon family AMPA receptor auxiliary protein 1
CTH cystathionine gamma-lyase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAD1 defender against cell death 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
ELANE elastase, neutrophil expressed
ENO2 enolase 2 (gamma, neuronal)
FAM129A family with sequence similarity 129, member A
GABARAPL1 GABA(A) receptor-associated protein like 1
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GARS glycyl-tRNA synthetase
GATA6 GATA binding protein 6
GLIPR1 GLI pathogenesis-related 1
GLRX glutaredoxin (thioltransferase)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
IFRD1 interferon-related developmental regulator 1
IL32 interleukin 32
INSIG2 insulin induced gene 2
KDM3A lysine (K)-specific demethylase 3A
KRT23 keratin 23, type I
LAMP2 lysosomal-associated membrane protein 2
LARP6 La ribonucleoprotein domain family, member 6
LGALS8 lectin, galactoside-binding, soluble, 8
LPAR2 lysophosphatidic acid receptor 2
MAN1A1 mannosidase, alpha, class 1A, member 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
OPN3 opsin 3
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HB prolyl 4-hydroxylase, beta polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA4 protein disulfide isomerase family A, member 4
PGM1 phosphoglucomutase 1
PLA2G16 phospholipase A2, group XVI
PLIN2 perilipin 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNMA2 paraneoplastic Ma antigen 2
PPAP2B phosphatidic acid phosphatase type 2B
PRUNE2 prune homolog 2 (Drosophila)
PSAP prosaposin
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTX3 pentraxin 3, long
QPCT glutaminyl-peptide cyclotransferase
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCRG1 stimulator of chondrogenesis 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC12A8 solute carrier family 12, member 8
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC16A4 solute carrier family 16, member 4
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
SORBS2 sorbin and SH3 domain containing 2
SPAG4 sperm associated antigen 4
SPG20 spastic paraplegia 20 (Troyer syndrome)
STC2 stanniocalcin 2
SYNGR3 synaptogyrin 3
TES testin LIM domain protein
TM2D1 TM2 domain containing 1
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TSC22D3 TSC22 domain family, member 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VIM vimentin
VLDLR very low density lipoprotein receptor
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
BST2 bone marrow stromal cell antigen 2
CCND1 cyclin D1
CD93 CD93 molecule
COL3A1 collagen, type III, alpha 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DLG5 discs, large homolog 5 (Drosophila)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBXO11 F-box protein 11
GPNMB glycoprotein (transmembrane) nmb
HELLS helicase, lymphoid-specific
HN1 hematological and neurological expressed 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ISG15 ISG15 ubiquitin-like modifier
KRT19 keratin 19, type I
KRT4 keratin 4, type II
LPL lipoprotein lipase
MAGEA3 melanoma antigen family A3
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPIPB3 nuclear pore complex interacting protein family, member B3
PODXL podocalyxin-like
PRKCD protein kinase C, delta
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RPS11 ribosomal protein S11
SFN stratifin
TNS3 tensin 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
XPO7 exportin 7
ZBTB20 zinc finger and BTB domain containing 20