BRD-K21025364_NVP-TAE226_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-K21025364_NVP-TAE226_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
APOD apolipoprotein D
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATF3 activating transcription factor 3
BANK1 B-cell scaffold protein with ankyrin repeats 1
BEX1 brain expressed, X-linked 1
C10ORF10 chromosome 10 open reading frame 10
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG2 cyclin G2
CD24 CD24 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLU clusterin
COL11A1 collagen, type XI, alpha 1
CST1 cystatin SN
CTGF connective tissue growth factor
CTSK cathepsin K
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DACH1 dachshund family transcription factor 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DST dystonin
FBLN1 fibulin 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXO4 forkhead box O4
FXYD3 FXYD domain containing ion transport regulator 3
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GSTM3 glutathione S-transferase mu 3 (brain)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFI6 interferon, alpha-inducible protein 6
IGFBP7 insulin-like growth factor binding protein 7
IRS1 insulin receptor substrate 1
ITGB5 integrin, beta 5
LTB lymphotoxin beta (TNF superfamily, member 3)
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MID1 midline 1
MMP7 matrix metallopeptidase 7
MT1G metallothionein 1G
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLK myosin light chain kinase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
OLFM4 olfactomedin 4
OSR2 odd-skipped related transciption factor 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PCP4 Purkinje cell protein 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PERP PERP, TP53 apoptosis effector
PIH1D1 PIH1 domain containing 1
PLAU plasminogen activator, urokinase
PLEKHA5 pleckstrin homology domain containing, family A member 5
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSPH phosphoserine phosphatase
QPCT glutaminyl-peptide cyclotransferase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RND3 Rho family GTPase 3
RSAD2 radical S-adenosyl methionine domain containing 2
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A6 solute carrier family 16, member 6
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SOCS2 suppressor of cytokine signaling 2
SQSTM1 sequestosome 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC1 stanniocalcin 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBX3 T-box 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM8 tripartite motif containing 8
WLS wntless Wnt ligand secretion mediator
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
APP amyloid beta (A4) precursor protein
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AUTS2 autism susceptibility candidate 2
BZW2 basic leucine zipper and W2 domains 2
C1ORF106 chromosome 1 open reading frame 106
CALML4 calmodulin-like 4
CCNB2 cyclin B2
CD34 CD34 molecule
CDC20 cell division cycle 20
COL9A3 collagen, type IX, alpha 3
CX3CR1 chemokine (C-X3-C motif) receptor 1
DLK1 delta-like 1 homolog (Drosophila)
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELAVL1 ELAV like RNA binding protein 1
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FNDC3B fibronectin type III domain containing 3B
FOLR1 folate receptor 1 (adult)
GPX3 glutathione peroxidase 3
GSTP1 glutathione S-transferase pi 1
GTF2A2 general transcription factor IIA, 2, 12kDa
HAL histidine ammonia-lyase
HIRA histone cell cycle regulator
HIST1H2BG histone cluster 1, H2bg
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITM2A integral membrane protein 2A
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LMNB1 lamin B1
LMO4 LIM domain only 4
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MLEC malectin
MSLN mesothelin
NEK2 NIMA-related kinase 2
NMU neuromedin U
ODC1 ornithine decarboxylase 1
PDLIM1 PDZ and LIM domain 1
PHGDH phosphoglycerate dehydrogenase
PSRC1 proline/serine-rich coiled-coil 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB5C RAB5C, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLPI secretory leukocyte peptidase inhibitor
TAGLN2 transgelin 2
TCTN1 tectonic family member 1
TRA2B transformer 2 beta homolog (Drosophila)
U2AF1 U2 small nuclear RNA auxiliary factor 1
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28