BRD-K21025364_NVP-TAE226_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-K21025364_NVP-TAE226_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGTR1 angiotensin II receptor, type 1
AKR1C3 aldo-keto reductase family 1, member C3
APOE apolipoprotein E
AQP9 aquaporin 9
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C6ORF48 chromosome 6 open reading frame 48
CBS cystathionine-beta-synthase
CCL4 chemokine (C-C motif) ligand 4
CP ceruloplasmin (ferroxidase)
CTSD cathepsin D
CYBB cytochrome b-245, beta polypeptide
CYFIP2 cytoplasmic FMR1 interacting protein 2
DHRS3 dehydrogenase/reductase (SDR family) member 3
DPYD dihydropyrimidine dehydrogenase
DST dystonin
EDNRB endothelin receptor type B
ELOVL5 ELOVL fatty acid elongase 5
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM65B family with sequence similarity 65, member B
FBP1 fructose-1,6-bisphosphatase 1
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FMO3 flavin containing monooxygenase 3
FMO5 flavin containing monooxygenase 5
FOXN3 forkhead box N3
GPR137B G protein-coupled receptor 137B
GREM1 gremlin 1, DAN family BMP antagonist
HNMT histamine N-methyltransferase
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LEF1 lymphoid enhancer-binding factor 1
LIMCH1 LIM and calponin homology domains 1
LOX lysyl oxidase
LY96 lymphocyte antigen 96
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MCTP1 multiple C2 domains, transmembrane 1
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
NEFL neurofilament, light polypeptide
NIPSNAP1 nipsnap homolog 1 (C. elegans)
OXTR oxytocin receptor
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDZK1IP1 PDZK1 interacting protein 1
PHGDH phosphoglycerate dehydrogenase
PLA1A phospholipase A1 member A
PNMA2 paraneoplastic Ma antigen 2
PON3 paraoxonase 3
PRKCA protein kinase C, alpha
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBKS ribokinase
SCP2 sterol carrier protein 2
SLC22A18 solute carrier family 22, member 18
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPAG16 sperm associated antigen 16
STC1 stanniocalcin 1
STS steroid sulfatase (microsomal), isozyme S
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGM2 transglutaminase 2
TLR4 toll-like receptor 4
TRIB2 tribbles pseudokinase 2
TST thiosulfate sulfurtransferase (rhodanese)
TWF2 twinfilin actin binding protein 2
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VNN1 vanin 1
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
APMAP adipocyte plasma membrane associated protein
AREG amphiregulin
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNE2 cyclin E2
CD24 CD24 molecule
CLU clusterin
DCN decorin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DONSON downstream neighbor of SON
EIF5A eukaryotic translation initiation factor 5A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FST follistatin
GINS2 GINS complex subunit 2 (Psf2 homolog)
HES1 hes family bHLH transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HOPX HOP homeobox
IGHM immunoglobulin heavy constant mu
ISLR immunoglobulin superfamily containing leucine-rich repeat
JAM3 junctional adhesion molecule 3
KIF20A kinesin family member 20A
KRT19 keratin 19, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MCM2 minichromosome maintenance complex component 2
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MELK maternal embryonic leucine zipper kinase
NPTX1 neuronal pentraxin I
ODC1 ornithine decarboxylase 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAGL1 pleiomorphic adenoma gene-like 1
PTRF polymerase I and transcript release factor
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLN sarcolipin
SOX9 SRY (sex determining region Y)-box 9
TACSTD2 tumor-associated calcium signal transducer 2
TMEM97 transmembrane protein 97
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
VDAC1 voltage-dependent anion channel 1