BRD-K21025364_NVP-TAE226_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

179 genes differentially expressed following the BRD-K21025364_NVP-TAE226_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL5 acyl-CoA synthetase long-chain family member 5
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDOA aldolase A, fructose-bisphosphate
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
ASS1 argininosuccinate synthase 1
ATP9A ATPase, class II, type 9A
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BTG1 B-cell translocation gene 1, anti-proliferative
C14ORF132 chromosome 14 open reading frame 132
C16ORF45 chromosome 16 open reading frame 45
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN3 calpain 3, (p94)
CCP110 centriolar coiled coil protein 110kDa
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CES1 carboxylesterase 1
COLEC12 collectin sub-family member 12
CSRP1 cysteine and glycine-rich protein 1
CST3 cystatin C
CXCL13 chemokine (C-X-C motif) ligand 13
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEPTOR DEP domain containing MTOR-interacting protein
DUSP10 dual specificity phosphatase 10
DUSP6 dual specificity phosphatase 6
DYNLT3 dynein, light chain, Tctex-type 3
EDNRA endothelin receptor type A
EML3 echinoderm microtubule associated protein like 3
EMP2 epithelial membrane protein 2
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB3 erb-b2 receptor tyrosine kinase 3
ETFB electron-transfer-flavoprotein, beta polypeptide
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV1 ets variant 1
FAM46A family with sequence similarity 46, member A
FGG fibrinogen gamma chain
FN1 fibronectin 1
FZD7 frizzled class receptor 7
GAS6 growth arrest-specific 6
GBP2 guanylate binding protein 2, interferon-inducible
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
GSTZ1 glutathione S-transferase zeta 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H2BK histone cluster 1, H2bk
HNMT histamine N-methyltransferase
HOOK2 hook microtubule-tethering protein 2
HOXD1 homeobox D1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM5B lysine (K)-specific demethylase 5B
KLF9 Kruppel-like factor 9
KRT19 keratin 19, type I
LDOC1 leucine zipper, down-regulated in cancer 1
LIMCH1 LIM and calponin homology domains 1
LXN latexin
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MN1 meningioma (disrupted in balanced translocation) 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NPDC1 neural proliferation, differentiation and control, 1
NRCAM neuronal cell adhesion molecule
NRN1 neuritin 1
OLFM1 olfactomedin 1
OPHN1 oligophrenin 1
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB4 phospholipase C, beta 4
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRAF2 PRA1 domain family, member 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A4 S100 calcium binding protein A4
SCAND1 SCAN domain containing 1
SCCPDH saccharopine dehydrogenase (putative)
SCD5 stearoyl-CoA desaturase 5
SFTPB surfactant protein B
SFTPC surfactant protein C
SFTPD surfactant protein D
SLC22A18 solute carrier family 22, member 18
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMYD3 SET and MYND domain containing 3
SOX2 SRY (sex determining region Y)-box 2
SPATA20 spermatogenesis associated 20
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SVIL supervillin
TCEAL4 transcription elongation factor A (SII)-like 4
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TNS1 tensin 1
TPD52L1 tumor protein D52-like 1
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TRIM22 tripartite motif containing 22
TSC22D1 TSC22 domain family, member 1
TSPAN7 tetraspanin 7
TST thiosulfate sulfurtransferase (rhodanese)
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VCAN versican
WAC WW domain containing adaptor with coiled-coil
WASF3 WAS protein family, member 3
WDTC1 WD and tetratricopeptide repeats 1
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ADI1 acireductone dioxygenase 1
ALDOB aldolase B, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
ANXA3 annexin A3
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BID BH3 interacting domain death agonist
BPHL biphenyl hydrolase-like (serine hydrolase)
C1ORF115 chromosome 1 open reading frame 115
CALML4 calmodulin-like 4
CANT1 calcium activated nucleotidase 1
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
DPT dermatopontin
ECT2 epithelial cell transforming 2
EIF5 eukaryotic translation initiation factor 5
ENOPH1 enolase-phosphatase 1
EPHA3 EPH receptor A3
EZR ezrin
FSCN1 fascin actin-bundling protein 1
GPRC5C G protein-coupled receptor, class C, group 5, member C
GTSE1 G-2 and S-phase expressed 1
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IFI27 interferon, alpha-inducible protein 27
ISG15 ISG15 ubiquitin-like modifier
KIF20A kinesin family member 20A
LMO4 LIM domain only 4
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MME membrane metallo-endopeptidase
MX1 MX dynamin-like GTPase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYBPC1 myosin binding protein C, slow type
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPD3 non-SMC condensin II complex, subunit D3
NR1H2 nuclear receptor subfamily 1, group H, member 2
PAK1IP1 PAK1 interacting protein 1
PBK PDZ binding kinase
PLAU plasminogen activator, urokinase
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RGS2 regulator of G-protein signaling 2
RNF6 ring finger protein (C3H2C3 type) 6
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A2 S100 calcium binding protein A2
SCGB2A2 secretoglobin, family 2A, member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
STK17A serine/threonine kinase 17a
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCL1A T-cell leukemia/lymphoma 1A
TCTN1 tectonic family member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUBB2A tubulin, beta 2A class IIa