BRD-K21025364_NVP-TAE226_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

101 genes differentially expressed following the BRD-K21025364_NVP-TAE226_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
AIM2 absent in melanoma 2
ALDOA aldolase A, fructose-bisphosphate
ARMCX2 armadillo repeat containing, X-linked 2
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BEX1 brain expressed, X-linked 1
C6ORF62 chromosome 6 open reading frame 62
CEMIP cell migration inducing protein, hyaluronan binding
CFI complement factor I
CHIC2 cysteine-rich hydrophobic domain 2
CHRDL1 chordin-like 1
CXCL14 chemokine (C-X-C motif) ligand 14
DAXX death-domain associated protein
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUSP6 dual specificity phosphatase 6
GAS1 growth arrest-specific 1
GAS7 growth arrest-specific 7
GLUL glutamate-ammonia ligase
HNMT histamine N-methyltransferase
IFI16 interferon, gamma-inducible protein 16
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
INTS3 integrator complex subunit 3
ITGA7 integrin, alpha 7
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
LOX lysyl oxidase
LXN latexin
MAGED1 melanoma antigen family D1
MFAP4 microfibrillar-associated protein 4
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
MMP2 matrix metallopeptidase 2
MSX1 msh homeobox 1
MX2 MX dynamin-like GTPase 2
MYH10 myosin, heavy chain 10, non-muscle
NREP neuronal regeneration related protein
NT5E 5'-nucleotidase, ecto (CD73)
PLN phospholamban
PNMA2 paraneoplastic Ma antigen 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RSAD2 radical S-adenosyl methionine domain containing 2
SASH1 SAM and SH3 domain containing 1
SCP2 sterol carrier protein 2
SDC2 syndecan 2
SELENBP1 selenium binding protein 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRSF6 serine/arginine-rich splicing factor 6
TCEAL4 transcription elongation factor A (SII)-like 4
TCF4 transcription factor 4
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM7SF2 transmembrane 7 superfamily member 2
TMEM2 transmembrane protein 2
TMOD1 tropomodulin 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VCAN versican
XAF1 XIAP associated factor 1

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
BTG3 BTG family, member 3
CAMP cathelicidin antimicrobial peptide
CCNE2 cyclin E2
CD24 CD24 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLTB clathrin, light chain B
CORO1C coronin, actin binding protein, 1C
CTSV cathepsin V
CXCL5 chemokine (C-X-C motif) ligand 5
EPHA3 EPH receptor A3
ERBB4 erb-b2 receptor tyrosine kinase 4
GRWD1 glutamate-rich WD repeat containing 1
HMOX1 heme oxygenase 1
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
IL17RB interleukin 17 receptor B
IPO13 importin 13
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT5 keratin 5, type II
LAMC2 laminin, gamma 2
LAPTM4B lysosomal protein transmembrane 4 beta
MMP12 matrix metallopeptidase 12
MRPS2 mitochondrial ribosomal protein S2
ODC1 ornithine decarboxylase 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRPF4 pre-mRNA processing factor 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A8 S100 calcium binding protein A8
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SQSTM1 sequestosome 1