BRD-K20755323_-666_SW620_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K20755323_-666_SW620_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA4 annexin A4
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BEX1 brain expressed, X-linked 1
BTG3 BTG family, member 3
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CLIC4 chloride intracellular channel 4
COLEC12 collectin sub-family member 12
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXADR coxsackie virus and adenovirus receptor
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK3 dickkopf WNT signaling pathway inhibitor 3
DSP desmoplakin
EDN1 endothelin 1
ELANE elastase, neutrophil expressed
ENO1 enolase 1, (alpha)
EXT1 exostosin glycosyltransferase 1
FHL2 four and a half LIM domains 2
FLNB filamin B, beta
FOSL1 FOS-like antigen 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GUSBP3 glucuronidase, beta pseudogene 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
IARS isoleucyl-tRNA synthetase
INPP1 inositol polyphosphate-1-phosphatase
KLF6 Kruppel-like factor 6
KLK5 kallikrein-related peptidase 5
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LGALS4 lectin, galactoside-binding, soluble, 4
LMO3 LIM domain only 3 (rhombotin-like 2)
MAP2K5 mitogen-activated protein kinase kinase 5
MMD monocyte to macrophage differentiation-associated
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NID1 nidogen 1
NT5E 5'-nucleotidase, ecto (CD73)
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIEZO2 piezo-type mechanosensitive ion channel component 2
PLAU plasminogen activator, urokinase
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC1 syndecan 1
SFRP1 secreted frizzled-related protein 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SQSTM1 sequestosome 1
SULF1 sulfatase 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS2 thrombospondin 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ASCL1 achaete-scute family bHLH transcription factor 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKA aurora kinase A
BST2 bone marrow stromal cell antigen 2
C3 complement component 3
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CLU clusterin
COBL cordon-bleu WH2 repeat protein
COL3A1 collagen, type III, alpha 1
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FABP7 fatty acid binding protein 7, brain
FAM107A family with sequence similarity 107, member A
FOLR1 folate receptor 1 (adult)
GPX3 glutathione peroxidase 3
GRWD1 glutamate-rich WD repeat containing 1
GYG1 glycogenin 1
HBB hemoglobin, beta
HOXC6 homeobox C6
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIF20A kinesin family member 20A
KLK11 kallikrein-related peptidase 11
LAMP5 lysosomal-associated membrane protein family, member 5
LEPR leptin receptor
MAOB monoamine oxidase B
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
OLFM1 olfactomedin 1
PBK PDZ binding kinase
PITX1 paired-like homeodomain 1
PLK1 polo-like kinase 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RHOBTB3 Rho-related BTB domain containing 3
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
SCGB2A1 secretoglobin, family 2A, member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SOX2 SRY (sex determining region Y)-box 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNS1 tensin 1
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIB2 tribbles pseudokinase 2
TXLNA taxilin alpha
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
ZBTB18 zinc finger and BTB domain containing 18