BRD-K20755323_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-K20755323_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACBD3 acyl-CoA binding domain containing 3
ACP5 acid phosphatase 5, tartrate resistant
AKR1C3 aldo-keto reductase family 1, member C3
ANXA10 annexin A10
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
CALU calumenin
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COMP cartilage oligomeric matrix protein
COTL1 coactosin-like F-actin binding protein 1
CRABP1 cellular retinoic acid binding protein 1
CTSZ cathepsin Z
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLX2 distal-less homeobox 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF5A eukaryotic translation initiation factor 5A
ELANE elastase, neutrophil expressed
FAM129A family with sequence similarity 129, member A
FKBP14 FK506 binding protein 14, 22 kDa
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA6 GATA binding protein 6
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBD hemoglobin, delta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
HYOU1 hypoxia up-regulated 1
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFRD1 interferon-related developmental regulator 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KDM3A lysine (K)-specific demethylase 3A
LAMP3 lysosomal-associated membrane protein 3
LAMP5 lysosomal-associated membrane protein family, member 5
LTF lactotransferrin
LY6E lymphocyte antigen 6 complex, locus E
MAGED1 melanoma antigen family D1
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP1B microtubule-associated protein 1B
MPO myeloperoxidase
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NKX3-1 NK3 homeobox 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PENK proenkephalin
PLAC8 placenta-specific 8
PLIN2 perilipin 2
PMP22 peripheral myelin protein 22
PPAP2B phosphatidic acid phosphatase type 2B
PRKCDBP protein kinase C, delta binding protein
PSAP prosaposin
PTGIS prostaglandin I2 (prostacyclin) synthase
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RHOB ras homolog family member B
RNASE4 ribonuclease, RNase A family, 4
RPS4Y1 ribosomal protein S4, Y-linked 1
RRBP1 ribosome binding protein 1
S100P S100 calcium binding protein P
SEC24D SEC24 family member D
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELL selectin L
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERTAD2 SERTA domain containing 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC16A4 solute carrier family 16, member 4
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SSR1 signal sequence receptor, alpha
STAT1 signal transducer and activator of transcription 1, 91kDa
STC2 stanniocalcin 2
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TES testin LIM domain protein
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM214 transmembrane protein 214
TMEM45A transmembrane protein 45A
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TSPAN13 tetraspanin 13
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAM1 vascular cell adhesion molecule 1
VIM vimentin
WARS tryptophanyl-tRNA synthetase
ZHX2 zinc fingers and homeoboxes 2
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ALB albumin
CAST calpastatin
CCND1 cyclin D1
CCND2 cyclin D2
CDKN2A cyclin-dependent kinase inhibitor 2A
CXADR coxsackie virus and adenovirus receptor
DHCR24 24-dehydrocholesterol reductase
FABP1 fatty acid binding protein 1, liver
FAIM Fas apoptotic inhibitory molecule
FASN fatty acid synthase
FGFR3 fibroblast growth factor receptor 3
GLUL glutamate-ammonia ligase
GRWD1 glutamate-rich WD repeat containing 1
H2AFV H2A histone family, member V
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INSIG1 insulin induced gene 1
KNG1 kininogen 1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRAS Kirsten rat sarcoma viral oncogene homolog
LDLR low density lipoprotein receptor
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTBP1 latent transforming growth factor beta binding protein 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MEIS1 Meis homeobox 1
PAEP progestagen-associated endometrial protein
PEG10 paternally expressed 10
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
POSTN periostin, osteoblast specific factor
S100A2 S100 calcium binding protein A2
SFN stratifin
SPINK1 serine peptidase inhibitor, Kazal type 1
TFRC transferrin receptor