BRD-K20742498_RS 39604 hydrochloride_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K20742498_RS 39604 hydrochloride_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANKRD10 ankyrin repeat domain 10
ANXA3 annexin A3
ARMCX1 armadillo repeat containing, X-linked 1
CA1 carbonic anhydrase I
CAPN2 calpain 2, (m/II) large subunit
CD46 CD46 molecule, complement regulatory protein
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR7 7-dehydrocholesterol reductase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
ELOVL5 ELOVL fatty acid elongase 5
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FBN2 fibrillin 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGFBP1 fibroblast growth factor binding protein 1
FLNA filamin A, alpha
GCH1 GTP cyclohydrolase 1
GLRX glutaredoxin (thioltransferase)
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL32 interleukin 32
INSIG1 insulin induced gene 1
INSM1 insulinoma-associated 1
IRS2 insulin receptor substrate 2
JUND jun D proto-oncogene
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MEIS1 Meis homeobox 1
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
MYO6 myosin VI
NSDHL NAD(P) dependent steroid dehydrogenase-like
OAZ1 ornithine decarboxylase antizyme 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SQLE squalene epoxidase
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VLDLR very low density lipoprotein receptor

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AQP3 aquaporin 3 (Gill blood group)
BAMBI BMP and activin membrane-bound inhibitor
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CHL1 cell adhesion molecule L1-like
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ICT1 immature colon carcinoma transcript 1
LXN latexin
MINA MYC induced nuclear antigen
MRPS7 mitochondrial ribosomal protein S7
NID2 nidogen 2 (osteonidogen)
NOP16 NOP16 nucleolar protein
NUP85 nucleoporin 85kDa
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
VWF von Willebrand factor
ZBTB16 zinc finger and BTB domain containing 16