BRD-K20742498_RS 39604 hydrochloride_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-K20742498_RS 39604 hydrochloride_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
BMP7 bone morphogenetic protein 7
CD36 CD36 molecule (thrombospondin receptor)
CLC Charcot-Leyden crystal galectin
COLEC12 collectin sub-family member 12
CPA3 carboxypeptidase A3 (mast cell)
CTSK cathepsin K
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FASN fatty acid synthase
FBN2 fibrillin 2
FCGBP Fc fragment of IgG binding protein
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GLRX glutaredoxin (thioltransferase)
GNPDA1 glucosamine-6-phosphate deaminase 1
GRN granulin
HHEX hematopoietically expressed homeobox
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KRT19 keratin 19, type I
LDOC1 leucine zipper, down-regulated in cancer 1
LPAR6 lysophosphatidic acid receptor 6
LYZ lysozyme
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP7 microtubule-associated protein 7
MBOAT7 membrane bound O-acyltransferase domain containing 7
MMP11 matrix metallopeptidase 11
MNDA myeloid cell nuclear differentiation antigen
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSMO1 methylsterol monooxygenase 1
MTMR11 myotubularin related protein 11
NR2F2 nuclear receptor subfamily 2, group F, member 2
NSDHL NAD(P) dependent steroid dehydrogenase-like
NTS neurotensin
ORAI3 ORAI calcium release-activated calcium modulator 3
PBX1 pre-B-cell leukemia homeobox 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
POR P450 (cytochrome) oxidoreductase
PPARD peroxisome proliferator-activated receptor delta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSD3 pleckstrin and Sec7 domain containing 3
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PYCARD PYD and CARD domain containing
RET ret proto-oncogene
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SOWAHC sosondowah ankyrin repeat domain family member C
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase
SQSTM1 sequestosome 1
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFBR3 transforming growth factor, beta receptor III
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM97 transmembrane protein 97
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
AK4 adenylate kinase 4
ALCAM activated leukocyte cell adhesion molecule
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AREG amphiregulin
ARL4A ADP-ribosylation factor-like 4A
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCL2L1 BCL2-like 1
BID BH3 interacting domain death agonist
BIRC3 baculoviral IAP repeat containing 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BZW2 basic leucine zipper and W2 domains 2
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CCNB2 cyclin B2
CD47 CD47 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFLAR CASP8 and FADD-like apoptosis regulator
COCH cochlin
CX3CL1 chemokine (C-X3-C motif) ligand 1
CYCS cytochrome c, somatic
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FERMT2 fermitin family member 2
GBP1 guanylate binding protein 1, interferon-inducible
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLS glutaminase
GOLT1B golgi transport 1B
GRB14 growth factor receptor-bound protein 14
GTF3A general transcription factor IIIA
HACD2 3-hydroxyacyl-CoA dehydratase 2
HAPLN1 hyaluronan and proteoglycan link protein 1
HILPDA hypoxia inducible lipid droplet-associated
HN1 hematological and neurological expressed 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ITGB1BP1 integrin beta 1 binding protein 1
KLHL7 kelch-like family member 7
KRAS Kirsten rat sarcoma viral oncogene homolog
LOX lysyl oxidase
LY75 lymphocyte antigen 75
MET MET proto-oncogene, receptor tyrosine kinase
NDRG1 N-myc downstream regulated 1
NRN1 neuritin 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OXTR oxytocin receptor
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAGL1 pleiomorphic adenoma gene-like 1
PSENEN presenilin enhancer gamma secretase subunit
REEP5 receptor accessory protein 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SMYD2 SET and MYND domain containing 2
SPINK1 serine peptidase inhibitor, Kazal type 1
SRI sorcin
SST somatostatin
SYBU syntabulin (syntaxin-interacting)
TFRC transferrin receptor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPM4 tropomyosin 4
TSPAN8 tetraspanin 8
UBE2E3 ubiquitin-conjugating enzyme E2E 3