BRD-K20526256_HG-14-10-04_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K20526256_HG-14-10-04_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
ANG angiogenin, ribonuclease, RNase A family, 5
APOA1 apolipoprotein A-I
ATP9A ATPase, class II, type 9A
AUTS2 autism susceptibility candidate 2
BCHE butyrylcholinesterase
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CBS cystathionine-beta-synthase
CLDN3 claudin 3
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
CTSD cathepsin D
DCN decorin
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ERBB3 erb-b2 receptor tyrosine kinase 3
EVL Enah/Vasp-like
FAM134B family with sequence similarity 134, member B
GAS1 growth arrest-specific 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
IFI16 interferon, gamma-inducible protein 16
INSR insulin receptor
ISLR immunoglobulin superfamily containing leucine-rich repeat
LDOC1 leucine zipper, down-regulated in cancer 1
LMCD1 LIM and cysteine-rich domains 1
MBNL2 muscleblind-like splicing regulator 2
MMP9 matrix metallopeptidase 9
MTSS1 metastasis suppressor 1
MXRA5 matrix-remodelling associated 5
MYO1D myosin ID
NNMT nicotinamide N-methyltransferase
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OPTN optineurin
PDLIM5 PDZ and LIM domain 5
PHGDH phosphoglycerate dehydrogenase
RAB40B RAB40B, member RAS oncogene family
RNASE4 ribonuclease, RNase A family, 4
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SPON1 spondin 1, extracellular matrix protein
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TOX3 TOX high mobility group box family member 3
TPM2 tropomyosin 2 (beta)
TRIM2 tripartite motif containing 2
TWIST1 twist family bHLH transcription factor 1
VGLL4 vestigial-like family member 4
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ANXA2 annexin A2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AZU1 azurocidin 1
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CDK1 cyclin-dependent kinase 1
CLC Charcot-Leyden crystal galectin
CLU clusterin
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CST7 cystatin F (leukocystatin)
CYB5A cytochrome b5 type A (microsomal)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELANE elastase, neutrophil expressed
FABP5 fatty acid binding protein 5 (psoriasis-associated)
G0S2 G0/G1 switch 2
GPX3 glutathione peroxidase 3
HPCAL1 hippocalcin-like 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
INHBB inhibin, beta B
KDM5D lysine (K)-specific demethylase 5D
KLK11 kallikrein-related peptidase 11
LTF lactotransferrin
MAL mal, T-cell differentiation protein
NRIP3 nuclear receptor interacting protein 3
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNASE3 ribonuclease, RNase A family, 3
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TYRP1 tyrosinase-related protein 1
UGCG UDP-glucose ceramide glucosyltransferase