BRD-K20285085_fostamatinib_HME1_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-K20285085_fostamatinib_HME1_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BST2 bone marrow stromal cell antigen 2
CBR3 carbonyl reductase 3
CCNG2 cyclin G2
CEP57 centrosomal protein 57kDa
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPE carboxypeptidase E
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DUSP1 dual specificity phosphatase 1
DUSP22 dual specificity phosphatase 22
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
ETV1 ets variant 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FRZB frizzled-related protein
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPX3 glutathione peroxidase 3
H2AFV H2A histone family, member V
HES1 hes family bHLH transcription factor 1
HMGB2 high mobility group box 2
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KRT15 keratin 15, type I
KRT17 keratin 17, type I
LPL lipoprotein lipase
MAOB monoamine oxidase B
METTL7A methyltransferase like 7A
MGP matrix Gla protein
N4BP2L1 NEDD4 binding protein 2-like 1
NFIB nuclear factor I/B
NR2F1 nuclear receptor subfamily 2, group F, member 1
PAWR PRKC, apoptosis, WT1, regulator
POSTN periostin, osteoblast specific factor
POU2AF1 POU class 2 associating factor 1
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS2 regulator of G-protein signaling 2
SCG5 secretogranin V
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
TMPRSS3 transmembrane protease, serine 3
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACKR3 atypical chemokine receptor 3
ADRB2 adrenoceptor beta 2, surface
CCND1 cyclin D1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CES1 carboxylesterase 1
CHGB chromogranin B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DHRS9 dehydrogenase/reductase (SDR family) member 9
DUSP14 dual specificity phosphatase 14
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F3 coagulation factor III (thromboplastin, tissue factor)
FOSL1 FOS-like antigen 1
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HOXA10 homeobox A10
HSPA2 heat shock 70kDa protein 2
ICAM1 intercellular adhesion molecule 1
KIF1BP KIF1 binding protein
LAPTM4B lysosomal protein transmembrane 4 beta
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NRG1 neuregulin 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB2A RAB2A, member RAS oncogene family
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SRSF6 serine/arginine-rich splicing factor 6
THBS1 thrombospondin 1
TNC tenascin C
TUBB2A tubulin, beta 2A class IIa
WNT5A wingless-type MMTV integration site family, member 5A
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1