BRD-K20285085_R406_HT29_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

219 genes differentially expressed following the BRD-K20285085_R406_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACSL5 acyl-CoA synthetase long-chain family member 5
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANKRD10 ankyrin repeat domain 10
ANXA4 annexin A4
ASS1 argininosuccinate synthase 1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
C1ORF106 chromosome 1 open reading frame 106
CA12 carbonic anhydrase XII
CALML4 calmodulin-like 4
CAT catalase
CD93 CD93 molecule
CDH17 cadherin 17, LI cadherin (liver-intestine)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CRABP2 cellular retinoic acid binding protein 2
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAPK1 death-associated protein kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DOK5 docking protein 5
EDN1 endothelin 1
EFNA1 ephrin-A1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FOXO4 forkhead box O4
FXYD3 FXYD domain containing ion transport regulator 3
GLRX glutaredoxin (thioltransferase)
GLTSCR2 glioma tumor suppressor candidate region gene 2
GSTK1 glutathione S-transferase kappa 1
HBP1 HMG-box transcription factor 1
HIST1H2BD histone cluster 1, H2bd
HLA-E major histocompatibility complex, class I, E
HNMT histamine N-methyltransferase
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IL32 interleukin 32
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ITGB4 integrin, beta 4
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM5D lysine (K)-specific demethylase 5D
KLF5 Kruppel-like factor 5 (intestinal)
MKRN1 makorin ring finger protein 1
MTMR11 myotubularin related protein 11
MVP major vault protein
MYO6 myosin VI
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NMRK1 nicotinamide riboside kinase 1
NUPR1 nuclear protein, transcriptional regulator, 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDZK1IP1 PDZK1 interacting protein 1
PLA1A phospholipase A1 member A
PLCB4 phospholipase C, beta 4
PLEKHA5 pleckstrin homology domain containing, family A member 5
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRUNE2 prune homolog 2 (Drosophila)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PYCARD PYD and CARD domain containing
RAP1GAP RAP1 GTPase activating protein
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRP1 arginine/serine-rich protein 1
RTN2 reticulon 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SFTPA2 surfactant protein A2
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPINK1 serine peptidase inhibitor, Kazal type 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TMEM176B transmembrane protein 176B
TOX thymocyte selection-associated high mobility group box
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TST thiosulfate sulfurtransferase (rhodanese)
USH1C Usher syndrome 1C (autosomal recessive, severe)
WDR13 WD repeat domain 13
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF580 zinc finger protein 580

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADCY3 adenylate cyclase 3
ADK adenosine kinase
AMD1 adenosylmethionine decarboxylase 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATF3 activating transcription factor 3
BLMH bleomycin hydrolase
BZW1 basic leucine zipper and W2 domains 1
C1QBP complement component 1, q subcomponent binding protein
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
COCH cochlin
COL6A2 collagen, type VI, alpha 2
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
CPE carboxypeptidase E
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP2 cysteine and glycine-rich protein 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTPS1 CTP synthase 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CYTL1 cytokine-like 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ELOVL5 ELOVL fatty acid elongase 5
EMP1 epithelial membrane protein 1
ENOSF1 enolase superfamily member 1
EPCAM epithelial cell adhesion molecule
EXO1 exonuclease 1
FAM129A family with sequence similarity 129, member A
FAM216A family with sequence similarity 216, member A
FASN fatty acid synthase
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPN3 GPN-loop GTPase 3
GTPBP4 GTP binding protein 4
HAT1 histone acetyltransferase 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HOMER1 homer scaffolding protein 1
HSPA14 heat shock 70kDa protein 14
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IFRD2 interferon-related developmental regulator 2
IL13RA2 interleukin 13 receptor, alpha 2
IL6ST interleukin 6 signal transducer
KIF14 kinesin family member 14
LAPTM4B lysosomal protein transmembrane 4 beta
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAK16 MAK16 homolog (S. cerevisiae)
MCM10 minichromosome maintenance complex component 10
MCUR1 mitochondrial calcium uniporter regulator 1
MMP3 matrix metallopeptidase 3
NAMPT nicotinamide phosphoribosyltransferase
NME1 NME/NM23 nucleoside diphosphate kinase 1
NUP98 nucleoporin 98kDa
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK1 polo-like kinase 1
PNO1 partner of NOB1 homolog (S. cerevisiae)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPAT phosphoribosyl pyrophosphate amidotransferase
PPIF peptidylprolyl isomerase F
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRMT1 protein arginine methyltransferase 1
RAD23B RAD23 homolog B (S. cerevisiae)
RPP40 ribonuclease P/MRP 40kDa subunit
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RTN1 reticulon 1
SACS sacsin molecular chaperone
SEH1L SEH1-like (S. cerevisiae)
SHCBP1 SHC SH2-domain binding protein 1
SMC2 structural maintenance of chromosomes 2
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SPC25 SPC25, NDC80 kinetochore complex component
SRM spermidine synthase
SRPX sushi-repeat containing protein, X-linked
SRSF3 serine/arginine-rich splicing factor 3
STEAP1 six transmembrane epithelial antigen of the prostate 1
TACC3 transforming, acidic coiled-coil containing protein 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TPX2 TPX2, microtubule-associated
TRA2B transformer 2 beta homolog (Drosophila)
TSPAN4 tetraspanin 4
TUBB2A tubulin, beta 2A class IIa
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBE2S ubiquitin-conjugating enzyme E2S
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
XIST X inactive specific transcript (non-protein coding)
YES1 YES proto-oncogene 1, Src family tyrosine kinase