BRD-K20123385_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-K20123385_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANGPTL2 angiopoietin-like 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOD apolipoprotein D
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
BEX4 brain expressed, X-linked 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CTGF connective tissue growth factor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
GADD45A growth arrest and DNA-damage-inducible, alpha
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
IFI27 interferon, alpha-inducible protein 27
IRF9 interferon regulatory factor 9
KRT23 keratin 23, type I
LCN2 lipocalin 2
MB myoglobin
MVP major vault protein
PECAM1 platelet/endothelial cell adhesion molecule 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PXDN peroxidasin
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SDC1 syndecan 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC22A18 solute carrier family 22, member 18
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TNNT1 troponin T type 1 (skeletal, slow)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
VAT1 vesicle amine transport 1
VWF von Willebrand factor

decreased expression

Symbol Name
AMD1 adenosylmethionine decarboxylase 1
ATAD2 ATPase family, AAA domain containing 2
ATF5 activating transcription factor 5
C8ORF4 chromosome 8 open reading frame 4
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CTPS1 CTP synthase 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
FEN1 flap structure-specific endonuclease 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HOPX HOP homeobox
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
LMO4 LIM domain only 4
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
PCNA proliferating cell nuclear antigen
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
SMC2 structural maintenance of chromosomes 2
TFRC transferrin receptor
TLR4 toll-like receptor 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C