BRD-K20000640_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-K20000640_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMDEC1 ADAM-like, decysin 1
ANXA1 annexin A1
ARG2 arginase 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASPN asporin
ATF3 activating transcription factor 3
BLNK B-cell linker
CD40 CD40 molecule, TNF receptor superfamily member 5
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH17 cadherin 17, LI cadherin (liver-intestine)
CEP70 centrosomal protein 70kDa
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHEK2 checkpoint kinase 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP4A charged multivesicular body protein 4A
COL8A2 collagen, type VIII, alpha 2
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSK cathepsin K
CXADR coxsackie virus and adenovirus receptor
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EDN1 endothelin 1
FABP4 fatty acid binding protein 4, adipocyte
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FN1 fibronectin 1
FXYD5 FXYD domain containing ion transport regulator 5
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
HBB hemoglobin, beta
HEPH hephaestin
HILPDA hypoxia inducible lipid droplet-associated
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA1598
LAPTM5 lysosomal protein transmembrane 5
LEF1 lymphoid enhancer-binding factor 1
LGALS4 lectin, galactoside-binding, soluble, 4
LPPR4 lipid phosphate phosphatase-related protein type 4
LXN latexin
LYZ lysozyme
MDK midkine (neurite growth-promoting factor 2)
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MT1M metallothionein 1M
MTMR11 myotubularin related protein 11
NBEA neurobeachin
NELL2 NEL-like 2 (chicken)
NID2 nidogen 2 (osteonidogen)
NTS neurotensin
PCLO piccolo presynaptic cytomatrix protein
PDE4B phosphodiesterase 4B, cAMP-specific
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
PRAME preferentially expressed antigen in melanoma
R3HDM2 R3H domain containing 2
RBM3 RNA binding motif (RNP1, RRM) protein 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN1 reticulon 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPT6 septin 6
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SOD2 superoxide dismutase 2, mitochondrial
SPP1 secreted phosphoprotein 1
SRGN serglycin
SST somatostatin
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYT1 synaptotagmin I
TM4SF1 transmembrane 4 L six family member 1
TM4SF4 transmembrane 4 L six family member 4
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TRIM2 tripartite motif containing 2
TSPAN7 tetraspanin 7
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAMP8 vesicle-associated membrane protein 8
VAV3 vav 3 guanine nucleotide exchange factor
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
AQP3 aquaporin 3 (Gill blood group)
CCND1 cyclin D1
CDA cytidine deaminase
CHERP calcium homeostasis endoplasmic reticulum protein
CLU clusterin
CNPY3 canopy FGF signaling regulator 3
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF3B eukaryotic translation initiation factor 3, subunit B
GRWD1 glutamate-rich WD repeat containing 1
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa
HOMER3 homer scaffolding protein 3
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
KIAA1551 KIAA1551
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
PODXL podocalyxin-like
PPIF peptidylprolyl isomerase F
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
RBPMS RNA binding protein with multiple splicing
RHOBTB3 Rho-related BTB domain containing 3
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SEPP1 selenoprotein P, plasma, 1
TPM4 tropomyosin 4
TUBB4B tubulin, beta 4B class IVb