BRD-K20000640_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

163 genes differentially expressed following the BRD-K20000640_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ANGPTL4 angiopoietin-like 4
ANXA1 annexin A1
C1R complement component 1, r subcomponent
C3 complement component 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD14 CD14 molecule
CD163 CD163 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFD complement factor D (adipsin)
COL1A1 collagen, type I, alpha 1
COL4A5 collagen, type IV, alpha 5
COL6A1 collagen, type VI, alpha 1
COLEC12 collectin sub-family member 12
CPA3 carboxypeptidase A3 (mast cell)
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DHRS7 dehydrogenase/reductase (SDR family) member 7
ECM1 extracellular matrix protein 1
EFNA1 ephrin-A1
ENO2 enolase 2 (gamma, neuronal)
F13A1 coagulation factor XIII, A1 polypeptide
FAM114A1 family with sequence similarity 114, member A1
FCGBP Fc fragment of IgG binding protein
FHL1 four and a half LIM domains 1
FOXO4 forkhead box O4
FSD1 fibronectin type III and SPRY domain containing 1
FXYD5 FXYD domain containing ion transport regulator 5
GAGE3 G antigen 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLRX glutaredoxin (thioltransferase)
GNAS GNAS complex locus
GYPC glycophorin C (Gerbich blood group)
HLA-B major histocompatibility complex, class I, B
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS1 lectin, galactoside-binding, soluble, 1
LIMCH1 LIM and calponin homology domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LPAR6 lysophosphatidic acid receptor 6
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MMD monocyte to macrophage differentiation-associated
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NELL2 NEL-like 2 (chicken)
NT5E 5'-nucleotidase, ecto (CD73)
PAM peptidylglycine alpha-amidating monooxygenase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDE8B phosphodiesterase 8B
PERP PERP, TP53 apoptosis effector
PGM1 phosphoglucomutase 1
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PON3 paraoxonase 3
PPAP2B phosphatidic acid phosphatase type 2B
PROCR protein C receptor, endothelial
PTN pleiotrophin
PYGL phosphorylase, glycogen, liver
RBP4 retinol binding protein 4, plasma
REEP1 receptor accessory protein 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP1 secreted frizzled-related protein 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOX9 SRY (sex determining region Y)-box 9
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STC1 stanniocalcin 1
TF transferrin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM2 tripartite motif containing 2
TSPAN5 tetraspanin 5
TXNIP thioredoxin interacting protein
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VIM vimentin
VSIG4 V-set and immunoglobulin domain containing 4
WLS wntless Wnt ligand secretion mediator
XIST X inactive specific transcript (non-protein coding)
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMT1 acidic residue methyltransferase 1
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDK4 cyclin-dependent kinase 4
CEP55 centrosomal protein 55kDa
CXCL13 chemokine (C-X-C motif) ligand 13
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EBNA1BP2 EBNA1 binding protein 2
EED embryonic ectoderm development
FAM35A family with sequence similarity 35, member A
FASTKD3 FAST kinase domains 3
FBXO11 F-box protein 11
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ICAM3 intercellular adhesion molecule 3
KIAA0125 KIAA0125
KIF14 kinesin family member 14
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KLK10 kallikrein-related peptidase 10
LIG1 ligase I, DNA, ATP-dependent
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MRPS30 mitochondrial ribosomal protein S30
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYCBP MYC binding protein
MYO5C myosin VC
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAT10 N-acetyltransferase 10 (GCN5-related)
NBN nibrin
NOLC1 nucleolar and coiled-body phosphoprotein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
ODC1 ornithine decarboxylase 1
OXTR oxytocin receptor
PAK1IP1 PAK1 interacting protein 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PNN pinin, desmosome associated protein
PPIF peptidylprolyl isomerase F
PRPF4 pre-mRNA processing factor 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTDSS1 phosphatidylserine synthase 1
RPP25 ribonuclease P/MRP 25kDa subunit
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP1B ribosomal RNA processing 1B
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SEH1L SEH1-like (S. cerevisiae)
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMC2 structural maintenance of chromosomes 2
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TFAM transcription factor A, mitochondrial
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPYL5 TSPY-like 5
VRK1 vaccinia related kinase 1
XBP1 X-box binding protein 1
XPO1 exportin 1
ZDHHC6 zinc finger, DHHC-type containing 6