BRD-K20000640_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K20000640_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ARG2 arginase 2
CAV1 caveolin 1, caveolae protein, 22kDa
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CECR1 cat eye syndrome chromosome region, candidate 1
CEMIP cell migration inducing protein, hyaluronan binding
CES1 carboxylesterase 1
COL15A1 collagen, type XV, alpha 1
COL4A1 collagen, type IV, alpha 1
COLEC12 collectin sub-family member 12
CRABP2 cellular retinoic acid binding protein 2
CXCR4 chemokine (C-X-C motif) receptor 4
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
FAM129A family with sequence similarity 129, member A
FOLR1 folate receptor 1 (adult)
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GLRX glutaredoxin (thioltransferase)
GPX3 glutathione peroxidase 3
GRB10 growth factor receptor-bound protein 10
GUSBP3 glucuronidase, beta pseudogene 3
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
ITM2A integral membrane protein 2A
IVNS1ABP influenza virus NS1A binding protein
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
L1CAM L1 cell adhesion molecule
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MEIS1 Meis homeobox 1
NEFH neurofilament, heavy polypeptide
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
OXCT1 3-oxoacid CoA transferase 1
PFKM phosphofructokinase, muscle
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLVAP plasmalemma vesicle associated protein
PRR15L proline rich 15-like
RGCC regulator of cell cycle
SCPEP1 serine carboxypeptidase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
SVIL supervillin
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPD52 tumor protein D52
TRIB2 tribbles pseudokinase 2

decreased expression

Symbol Name
CORO1B coronin, actin binding protein, 1B
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
KDM2A lysine (K)-specific demethylase 2A
MGLL monoglyceride lipase
MTCL1 microtubule crosslinking factor 1
MYRF myelin regulatory factor
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PXMP2 peroxisomal membrane protein 2, 22kDa
TMEM134 transmembrane protein 134
TOR1A torsin family 1, member A (torsin A)
UBE2E3 ubiquitin-conjugating enzyme E2E 3