BRD-K19796430_LDE225 (NVP-LDE225)_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K19796430_LDE225 (NVP-LDE225)_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADA adenosine deaminase
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGAP29 Rho GTPase activating protein 29
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
BEX4 brain expressed, X-linked 4
BSG basigin (Ok blood group)
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CD2AP CD2-associated protein
CD44 CD44 molecule (Indian blood group)
CD46 CD46 molecule, complement regulatory protein
CNN3 calponin 3, acidic
CPB1 carboxypeptidase B1 (tissue)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEPTOR DEP domain containing MTOR-interacting protein
DUSP5 dual specificity phosphatase 5
EREG epiregulin
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GSDMB gasdermin B
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
GUSBP11 glucuronidase, beta pseudogene 11
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGN4 high mobility group nucleosomal binding domain 4
HOXB2 homeobox B2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI16 interferon, gamma-inducible protein 16
IFIH1 interferon induced with helicase C domain 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
INSIG1 insulin induced gene 1
IPO13 importin 13
JCHAIN joining chain of multimeric IgA and IgM
LPAR6 lysophosphatidic acid receptor 6
LYN LYN proto-oncogene, Src family tyrosine kinase
MAN1A1 mannosidase, alpha, class 1A, member 1
MFAP5 microfibrillar associated protein 5
MMD monocyte to macrophage differentiation-associated
MPZL2 myelin protein zero-like 2
MSN moesin
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYO1D myosin ID
NT5E 5'-nucleotidase, ecto (CD73)
NVL nuclear VCP-like
OAT ornithine aminotransferase
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
POU2AF1 POU class 2 associating factor 1
PRKCI protein kinase C, iota
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RAB38 RAB38, member RAS oncogene family
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SAT1 spermidine/spermine N1-acetyltransferase 1
SHB Src homology 2 domain containing adaptor protein B
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPON2 spondin 2, extracellular matrix protein
SST somatostatin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TDO2 tryptophan 2,3-dioxygenase
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TPD52 tumor protein D52
TPST2 tyrosylprotein sulfotransferase 2
TRIM13 tripartite motif containing 13
UBE2L6 ubiquitin-conjugating enzyme E2L 6
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CFD complement factor D (adipsin)
CLTB clathrin, light chain B
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPYSL2 dihydropyrimidinase-like 2
E2F2 E2F transcription factor 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
HOMER1 homer scaffolding protein 1
HOXC10 homeobox C10
HOXC6 homeobox C6
HSPB8 heat shock 22kDa protein 8
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KLK11 kallikrein-related peptidase 11
LPL lipoprotein lipase
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NPR3 natriuretic peptide receptor 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCDH9 protocadherin 9
PEBP1 phosphatidylethanolamine binding protein 1
PIP prolactin-induced protein
PTGDS prostaglandin D2 synthase 21kDa (brain)
RHOBTB3 Rho-related BTB domain containing 3
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SET SET nuclear proto-oncogene
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
SYNM synemin, intermediate filament protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)