BRD-K19724398_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

224 genes differentially expressed following the BRD-K19724398_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACE2 angiotensin I converting enzyme 2
ACO2 aconitase 2, mitochondrial
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANOS1 anosmin 1
APLP2 amyloid beta (A4) precursor-like protein 2
APOLD1 apolipoprotein L domain containing 1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BASP1 brain abundant, membrane attached signal protein 1
BCHE butyrylcholinesterase
BSG basigin (Ok blood group)
BTG2 BTG family, member 2
CALR calreticulin
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CD9 CD9 molecule
CDK19 cyclin-dependent kinase 19
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CKB creatine kinase, brain
CKM creatine kinase, muscle
CLGN calmegin
CLIC5 chloride intracellular channel 5
CNN3 calponin 3, acidic
COL6A2 collagen, type VI, alpha 2
COLEC12 collectin sub-family member 12
CORO1A coronin, actin binding protein, 1A
CPM carboxypeptidase M
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXADR coxsackie virus and adenovirus receptor
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DES desmin
DKK2 dickkopf WNT signaling pathway inhibitor 2
DPYSL3 dihydropyrimidinase-like 3
DST dystonin
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMX2 empty spiracles homeobox 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FKBP1A FK506 binding protein 1A, 12kDa
FN1 fibronectin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXF1 forkhead box F1
FOXN3 forkhead box N3
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
GPC3 glypican 3
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
H3F3B H3 histone, family 3B (H3.3B)
HECA headcase homolog (Drosophila)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IRS2 insulin receptor substrate 2
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
KRT20 keratin 20, type I
LAMP3 lysosomal-associated membrane protein 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
MEF2A myocyte enhancer factor 2A
MEF2C myocyte enhancer factor 2C
MFAP2 microfibrillar-associated protein 2
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYH11 myosin, heavy chain 11, smooth muscle
NID1 nidogen 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NXN nucleoredoxin
ODC1 ornithine decarboxylase 1
P3H2 prolyl 3-hydroxylase 2
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PBX3 pre-B-cell leukemia homeobox 3
PDLIM3 PDZ and LIM domain 3
PELI1 pellino E3 ubiquitin protein ligase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRDX2 peroxiredoxin 2
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RBM8A RNA binding motif protein 8A
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RRAD Ras-related associated with diabetes
SCGB1D2 secretoglobin, family 1D, member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SOX11 SRY (sex determining region Y)-box 11
SPON1 spondin 1, extracellular matrix protein
SPRY4 sprouty homolog 4 (Drosophila)
TCF21 transcription factor 21
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOX3 TOX high mobility group box family member 3
TSPAN12 tetraspanin 12
TST thiosulfate sulfurtransferase (rhodanese)
UBE3B ubiquitin protein ligase E3B
VIM vimentin
WWTR1 WW domain containing transcription regulator 1
YPEL5 yippee-like 5 (Drosophila)
ZDHHC11 zinc finger, DHHC-type containing 11
ZEB1 zinc finger E-box binding homeobox 1

decreased expression

Symbol Name
ADA adenosine deaminase
AHNAK2 AHNAK nucleoprotein 2
ARMT1 acidic residue methyltransferase 1
B3GNT1
BIRC2 baculoviral IAP repeat containing 2
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNF cyclin F
CD14 CD14 molecule
CDCA4 cell division cycle associated 4
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CFD complement factor D (adipsin)
CHMP6 charged multivesicular body protein 6
CLK4 CDC-like kinase 4
COL14A1 collagen, type XIV, alpha 1
CSTA cystatin A (stefin A)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DENND2D DENN/MADD domain containing 2D
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP22 dual specificity phosphatase 22
EIF5 eukaryotic translation initiation factor 5
ERLIN1 ER lipid raft associated 1
ESR1 estrogen receptor 1
EXOSC4 exosome component 4
FCGBP Fc fragment of IgG binding protein
FOLR1 folate receptor 1 (adult)
GABPB1 GA binding protein transcription factor, beta subunit 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA3 GATA binding protein 3
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLHL9 kelch-like family member 9
KRT14 keratin 14, type I
KYNU kynureninase
LYZ lysozyme
METTL7A methyltransferase like 7A
MREG melanoregulin
MSL1 male-specific lethal 1 homolog (Drosophila)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NCK1 NCK adaptor protein 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NET1 neuroepithelial cell transforming 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOP16 NOP16 nucleolar protein
NOV nephroblastoma overexpressed
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PARP2 poly (ADP-ribose) polymerase 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLK1 polo-like kinase 1
PNN pinin, desmosome associated protein
PROM1 prominin 1
PTGES prostaglandin E synthase
PTMA prothymosin, alpha
RANBP6 RAN binding protein 6
RBM47 RNA binding motif protein 47
RGS4 regulator of G-protein signaling 4
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUFY3 RUN and FYVE domain containing 3
SCRG1 stimulator of chondrogenesis 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SNX11 sorting nexin 11
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
STC2 stanniocalcin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFB3 transforming growth factor, beta 3
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TRIM29 tripartite motif containing 29
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSKU tsukushi, small leucine rich proteoglycan
XBP1 X-box binding protein 1