BRD-K19724398_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

288 genes differentially expressed following the BRD-K19724398_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACSL3 acyl-CoA synthetase long-chain family member 3
AKIRIN1 akirin 1
APLP2 amyloid beta (A4) precursor-like protein 2
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BHLHE40 basic helix-loop-helix family, member e40
BMP7 bone morphogenetic protein 7
BTG2 BTG family, member 2
C1ORF116 chromosome 1 open reading frame 116
CADM1 cell adhesion molecule 1
CAPG capping protein (actin filament), gelsolin-like
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCDC92 coiled-coil domain containing 92
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CD52 CD52 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CKB creatine kinase, brain
CLIC3 chloride intracellular channel 3
COTL1 coactosin-like F-actin binding protein 1
CPM carboxypeptidase M
CTSL cathepsin L
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EAPP E2F-associated phosphoprotein
EGR2 early growth response 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPAS1 endothelial PAS domain protein 1
EPHA2 EPH receptor A2
EPS8L2 EPS8-like 2
FABP7 fatty acid binding protein 7, brain
FGFR3 fibroblast growth factor receptor 3
FHOD3 formin homology 2 domain containing 3
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA2 GATA binding protein 2
GPC1 glypican 1
GSE1 Gse1 coiled-coil protein
GSN gelsolin
HBEGF heparin-binding EGF-like growth factor
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IL32 interleukin 32
INHBB inhibin, beta B
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
JAG1 jagged 1
JAG2 jagged 2
KCTD5 potassium channel tetramerization domain containing 5
KDM6B lysine (K)-specific demethylase 6B
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LGALS3 lectin, galactoside-binding, soluble, 3
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
MYO6 myosin VI
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NEB nebulin
NEBL nebulette
NEFH neurofilament, heavy polypeptide
NT5E 5'-nucleotidase, ecto (CD73)
OPN3 opsin 3
PBX3 pre-B-cell leukemia homeobox 3
PCDH9 protocadherin 9
PDGFA platelet-derived growth factor alpha polypeptide
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PERP PERP, TP53 apoptosis effector
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
POSTN periostin, osteoblast specific factor
PPL periplakin
PRKCZ protein kinase C, zeta
PRNP prion protein
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPRE protein tyrosine phosphatase, receptor type, E
RAB11FIP1 RAB11 family interacting protein 1 (class I)
REEP1 receptor accessory protein 1
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERTAD2 SERTA domain containing 2
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX9 SRY (sex determining region Y)-box 9
STAT1 signal transducer and activator of transcription 1, 91kDa
TBX3 T-box 3
TF transferrin
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TIGAR TP53 induced glycolysis regulatory phosphatase
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TRIM29 tripartite motif containing 29
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
YPEL5 yippee-like 5 (Drosophila)
ZFAND5 zinc finger, AN1-type domain 5
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADSL adenylosuccinate lyase
AKR1C3 aldo-keto reductase family 1, member C3
AMDHD2 amidohydrolase domain containing 2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX6 armadillo repeat containing, X-linked 6
ARMT1 acidic residue methyltransferase 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
C3 complement component 3
C4ORF27 chromosome 4 open reading frame 27
CA12 carbonic anhydrase XII
CACYBP calcyclin binding protein
CCNA2 cyclin A2
CD200 CD200 molecule
CD34 CD34 molecule
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPN centromere protein N
CFB complement factor B
CHEK2 checkpoint kinase 2
CP ceruloplasmin (ferroxidase)
CRYZ crystallin, zeta (quinone reductase)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL12 chemokine (C-X-C motif) ligand 12
DCK deoxycytidine kinase
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUT deoxyuridine triphosphatase
ECI2 enoyl-CoA delta isomerase 2
EFCAB11 EF-hand calcium binding domain 11
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
EPRS glutamyl-prolyl-tRNA synthetase
ERLIN1 ER lipid raft associated 1
ESR1 estrogen receptor 1
FAM35A family with sequence similarity 35, member A
GABPB1 GA binding protein transcription factor, beta subunit 1
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HAUS4 HAUS augmin-like complex, subunit 4
HIST1H4J histone cluster 1, H4j
HMMR hyaluronan-mediated motility receptor (RHAMM)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFI16 interferon, gamma-inducible protein 16
IFI44 interferon-induced protein 44
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LAMA4 laminin, alpha 4
LMNB1 lamin B1
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPLA1 lysophospholipase I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MCTS1 malignant T cell amplified sequence 1
MELK maternal embryonic leucine zipper kinase
METTL1 methyltransferase like 1
MGST2 microsomal glutathione S-transferase 2
MRPL12 mitochondrial ribosomal protein L12
MRPL15 mitochondrial ribosomal protein L15
MRPS30 mitochondrial ribosomal protein S30
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MUC16 mucin 16, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NCAPG non-SMC condensin I complex, subunit G
NDC1 NDC1 transmembrane nucleoporin
NET1 neuroepithelial cell transforming 1
NHP2 NHP2 ribonucleoprotein
NIT2 nitrilase family, member 2
NLE1 notchless homolog 1 (Drosophila)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NPM3 nucleophosmin/nucleoplasmin 3
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21
NUP107 nucleoporin 107kDa
NUP85 nucleoporin 85kDa
ORC5 origin recognition complex, subunit 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PHGDH phosphoglycerate dehydrogenase
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX4 peroxiredoxin 4
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PXDN peroxidasin
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RGS4 regulator of G-protein signaling 4
RNASEH2A ribonuclease H2, subunit A
RUVBL1 RuvB-like AAA ATPase 1
SCP2 sterol carrier protein 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
TARS threonyl-tRNA synthetase
TCF4 transcription factor 4
TFF3 trefoil factor 3 (intestinal)
TIMELESS timeless circadian clock
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPIN TIMELESS interacting protein
TMEM109 transmembrane protein 109
TMEM126B transmembrane protein 126B
TMEM14A transmembrane protein 14A
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UGCG UDP-glucose ceramide glucosyltransferase
WDR12 WD repeat domain 12
WDR3 WD repeat domain 3
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
ZWILCH zwilch kinetochore protein