BRD-K19724398_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K19724398_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADM adrenomedullin
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
ATF5 activating transcription factor 5
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
C3ORF14 chromosome 3 open reading frame 14
CAB39 calcium binding protein 39
CEP350 centrosomal protein 350kDa
CLDN10 claudin 10
CLIC2 chloride intracellular channel 2
COLEC12 collectin sub-family member 12
CPM carboxypeptidase M
CSNK2A2 casein kinase 2, alpha prime polypeptide
CYTH1 cytohesin 1
DEFB1 defensin, beta 1
DPYD dihydropyrimidine dehydrogenase
DSE dermatan sulfate epimerase
EGLN3 egl-9 family hypoxia-inducible factor 3
EMP3 epithelial membrane protein 3
EMX2 empty spiracles homeobox 2
F13A1 coagulation factor XIII, A1 polypeptide
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FLRT3 fibronectin leucine rich transmembrane protein 3
FZD7 frizzled class receptor 7
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
HIST1H2BD histone cluster 1, H2bd
HIST3H2A histone cluster 3, H2a
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
ITM2C integral membrane protein 2C
LPAR1 lysophosphatidic acid receptor 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MKNK2 MAP kinase interacting serine/threonine kinase 2
MSMO1 methylsterol monooxygenase 1
NMU neuromedin U
NT5E 5'-nucleotidase, ecto (CD73)
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
OSER1 oxidative stress responsive serine-rich 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PI3 peptidase inhibitor 3, skin-derived
PRKCB protein kinase C, beta
PRKD3 protein kinase D3
RSRP1 arginine/serine-rich protein 1
S100A8 S100 calcium binding protein A8
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
ST7 suppression of tumorigenicity 7
TDO2 tryptophan 2,3-dioxygenase
THSD7A thrombospondin, type I, domain containing 7A
TKTL1 transketolase-like 1
TMEM176B transmembrane protein 176B
TSPAN31 tetraspanin 31
TWIST1 twist family bHLH transcription factor 1
TXNIP thioredoxin interacting protein
UBL5 ubiquitin-like 5
VIM vimentin
ZCCHC14 zinc finger, CCHC domain containing 14
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMDHD2 amidohydrolase domain containing 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
C2CD5 C2 calcium-dependent domain containing 5
CALD1 caldesmon 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHMP6 charged multivesicular body protein 6
COL1A2 collagen, type I, alpha 2
COL9A3 collagen, type IX, alpha 3
CXCL8 chemokine (C-X-C motif) ligand 8
DCK deoxycytidine kinase
DMD dystrophin
ENAH enabled homolog (Drosophila)
EPRS glutamyl-prolyl-tRNA synthetase
GABPB1 GA binding protein transcription factor, beta subunit 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GUSBP11 glucuronidase, beta pseudogene 11
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
JCHAIN joining chain of multimeric IgA and IgM
KCTD5 potassium channel tetramerization domain containing 5
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LTBP2 latent transforming growth factor beta binding protein 2
LYZ lysozyme
MCAM melanoma cell adhesion molecule
MYC v-myc avian myelocytomatosis viral oncogene homolog
NRG1 neuregulin 1
OAT ornithine aminotransferase
OLFML2A olfactomedin-like 2A
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PON2 paraoxonase 2
PON3 paraoxonase 3
PPA1 pyrophosphatase (inorganic) 1
PRELP proline/arginine-rich end leucine-rich repeat protein
RPIA ribose 5-phosphate isomerase A
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELENBP1 selenium binding protein 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TM4SF1 transmembrane 4 L six family member 1
TYMP thymidine phosphorylase