BRD-K19724398_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

219 genes differentially expressed following the BRD-K19724398_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHR aryl hydrocarbon receptor
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANKRD10 ankyrin repeat domain 10
AOC3 amine oxidase, copper containing 3
APLP2 amyloid beta (A4) precursor-like protein 2
APOC1 apolipoprotein C-I
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ASPN asporin
BAMBI BMP and activin membrane-bound inhibitor
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CALCRL calcitonin receptor-like
CALR calreticulin
CCNG2 cyclin G2
CD36 CD36 molecule (thrombospondin receptor)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC11A C-type lectin domain family 11, member A
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CPM carboxypeptidase M
CSNK1A1 casein kinase 1, alpha 1
CSNK2A2 casein kinase 2, alpha prime polypeptide
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DCHS1 dachsous cadherin-related 1
DCN decorin
DENND1B DENN/MADD domain containing 1B
DUSP6 dual specificity phosphatase 6
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFHD1 EF-hand domain family, member D1
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FASTKD5 FAST kinase domains 5
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FLRT3 fibronectin leucine rich transmembrane protein 3
FLT1 fms-related tyrosine kinase 1
FNBP1L formin binding protein 1-like
FRY furry homolog (Drosophila)
GDF15 growth differentiation factor 15
GNAS GNAS complex locus
GSN gelsolin
HECA headcase homolog (Drosophila)
HES1 hes family bHLH transcription factor 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HOMER1 homer scaffolding protein 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA1A heat shock 70kDa protein 1A
INHBB inhibin, beta B
INSIG1 insulin induced gene 1
JAG1 jagged 1
KDM3A lysine (K)-specific demethylase 3A
KLF11 Kruppel-like factor 11
LAMP3 lysosomal-associated membrane protein 3
LGALS3 lectin, galactoside-binding, soluble, 3
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP11 matrix metallopeptidase 11
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
MTUS1 microtubule associated tumor suppressor 1
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NID1 nidogen 1
NT5E 5'-nucleotidase, ecto (CD73)
OSR2 odd-skipped related transciption factor 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PBX1 pre-B-cell leukemia homeobox 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM3 PDZ and LIM domain 3
PELI1 pellino E3 ubiquitin protein ligase 1
PLN phospholamban
PLVAP plasmalemma vesicle associated protein
POSTN periostin, osteoblast specific factor
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRNP prion protein
PTPRE protein tyrosine phosphatase, receptor type, E
RB1CC1 RB1-inducible coiled-coil 1
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RGS16 regulator of G-protein signaling 16
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRAGD Ras-related GTP binding D
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCN3A sodium channel, voltage gated, type III alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC38A2 solute carrier family 38, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SORBS1 sorbin and SH3 domain containing 1
SOX4 SRY (sex determining region Y)-box 4
SPARCL1 SPARC-like 1 (hevin)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SST somatostatin
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBPL1 TBP-like 1
TFRC transferrin receptor
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TM6SF1 transmembrane 6 superfamily member 1
TNNT1 troponin T type 1 (skeletal, slow)
TOX3 TOX high mobility group box family member 3
TRIB2 tribbles pseudokinase 2
WASF1 WAS protein family, member 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AHNAK AHNAK nucleoprotein
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANXA6 annexin A6
AUTS2 autism susceptibility candidate 2
CCNA2 cyclin A2
CCND1 cyclin D1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DHRS7 dehydrogenase/reductase (SDR family) member 7
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNMBP dynamin binding protein
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
EGFR epidermal growth factor receptor
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FOXC1 forkhead box C1
FTH1 ferritin, heavy polypeptide 1
FUS FUS RNA binding protein
GABPB1 GA binding protein transcription factor, beta subunit 1
GLIPR1 GLI pathogenesis-related 1
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXA10 homeobox A10
HOXA5 homeobox A5
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
IRAK1 interleukin-1 receptor-associated kinase 1
JMJD6 jumonji domain containing 6
KAZN kazrin, periplakin interacting protein
KIAA0125 KIAA0125
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KLC1 kinesin light chain 1
KRT10 keratin 10, type I
LOX lysyl oxidase
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOK MOK protein kinase
MRPL12 mitochondrial ribosomal protein L12
MSL1 male-specific lethal 1 homolog (Drosophila)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOV nephroblastoma overexpressed
NRG1 neuregulin 1
NRIP1 nuclear receptor interacting protein 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
PAPOLA poly(A) polymerase alpha
PAX8 paired box 8
PDLIM2 PDZ and LIM domain 2 (mystique)
PFKL phosphofructokinase, liver
PLAUR plasminogen activator, urokinase receptor
PRC1 protein regulator of cytokinesis 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTX3 pentraxin 3, long
QDPR quinoid dihydropteridine reductase
QPRT quinolinate phosphoribosyltransferase
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBM34 RNA binding motif protein 34
RFC2 replication factor C (activator 1) 2, 40kDa
RPL10 ribosomal protein L10
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
SCAND1 SCAN domain containing 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SGSH N-sulfoglucosamine sulfohydrolase
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAD3 SMAD family member 3
SORD sorbitol dehydrogenase
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
SRSF5 serine/arginine-rich splicing factor 5
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNPO1 transportin 1
TRAF5 TNF receptor-associated factor 5
TRIP6 thyroid hormone receptor interactor 6
U2AF1 U2 small nuclear RNA auxiliary factor 1