BRD-K19687926_lapatinib_SKBR3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

167 genes differentially expressed following the BRD-K19687926_lapatinib_SKBR3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ANKRD10 ankyrin repeat domain 10
APOD apolipoprotein D
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ASMTL acetylserotonin O-methyltransferase-like
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
C14ORF132 chromosome 14 open reading frame 132
CALML5 calmodulin-like 5
CAPN1 calpain 1, (mu/I) large subunit
CAPN2 calpain 2, (m/II) large subunit
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COMT catechol-O-methyltransferase
DEFB1 defensin, beta 1
DRAM1 DNA-damage regulated autophagy modulator 1
EIF3D eukaryotic translation initiation factor 3, subunit D
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM63A family with sequence similarity 63, member A
FBP1 fructose-1,6-bisphosphatase 1
FMO5 flavin containing monooxygenase 5
FUCA1 fucosidase, alpha-L- 1, tissue
FZD6 frizzled class receptor 6
GPR137B G protein-coupled receptor 137B
GSTM2 glutathione S-transferase mu 2 (muscle)
H1F0 H1 histone family, member 0
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HBB hemoglobin, beta
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HNMT histamine N-methyltransferase
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA2 heat shock 70kDa protein 2
IGSF3 immunoglobulin superfamily, member 3
KAT6B K(lysine) acetyltransferase 6B
LAMA3 laminin, alpha 3
MECOM MDS1 and EVI1 complex locus
MLPH melanophilin
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYO6 myosin VI
NBPF10 neuroblastoma breakpoint family, member 10
NCALD neurocalcin delta
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PPL periplakin
RAB17 RAB17, member RAS oncogene family
RANBP2 RAN binding protein 2
REEP5 receptor accessory protein 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SECISBP2L SECIS binding protein 2-like
SFTPC surfactant protein C
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC22A18 solute carrier family 22, member 18
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
AEBP1 AE binding protein 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMD1 adenosylmethionine decarboxylase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASNS asparagine synthetase (glutamine-hydrolyzing)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BTG3 BTG family, member 3
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCND2 cyclin D2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEP55 centrosomal protein 55kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CKS2 CDC28 protein kinase regulatory subunit 2
COL11A1 collagen, type XI, alpha 1
CORO1A coronin, actin binding protein, 1A
CXADR coxsackie virus and adenovirus receptor
CYR61 cysteine-rich, angiogenic inducer, 61
DCK deoxycytidine kinase
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
E2F2 E2F transcription factor 2
EBP emopamil binding protein (sterol isomerase)
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAS Fas cell surface death receptor
FOLR1 folate receptor 1 (adult)
FRZB frizzled-related protein
GBP1 guanylate binding protein 1, interferon-inducible
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
GPX3 glutathione peroxidase 3
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAGE3 L antigen family, member 3
LEF1 lymphoid enhancer-binding factor 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAK16 MAK16 homolog (S. cerevisiae)
MELK maternal embryonic leucine zipper kinase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NKX3-1 NK3 homeobox 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOP16 NOP16 nucleolar protein
NR2F6 nuclear receptor subfamily 2, group F, member 6
ODC1 ornithine decarboxylase 1
PCP4 Purkinje cell protein 4
PI3 peptidase inhibitor 3, skin-derived
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SFN stratifin
SIVA1 SIVA1, apoptosis-inducing factor
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STMN1 stathmin 1
SULF1 sulfatase 1
TACC3 transforming, acidic coiled-coil containing protein 3
TESC tescalcin
TMEM97 transmembrane protein 97
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein