BRD-K19687926_lapatinib_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K19687926_lapatinib_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
BCHE butyrylcholinesterase
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CFB complement factor B
CFH complement factor H
CLU clusterin
CP ceruloplasmin (ferroxidase)
CPA3 carboxypeptidase A3 (mast cell)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
GJA1 gap junction protein, alpha 1, 43kDa
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NMU neuromedin U
NUPR1 nuclear protein, transcriptional regulator, 1
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PODXL podocalyxin-like
PVALB parvalbumin
RCAN2 regulator of calcineurin 2
RGS1 regulator of G-protein signaling 1
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
TDO2 tryptophan 2,3-dioxygenase
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDCP1 CUB domain containing protein 1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAR2 fatty acyl CoA reductase 2
FERMT1 fermitin family member 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GOLGA8A golgin A8 family, member A
GPRC5A G protein-coupled receptor, class C, group 5, member A
HAS2 hyaluronan synthase 2
HBEGF heparin-binding EGF-like growth factor
HEPH hephaestin
HMGA2 high mobility group AT-hook 2
IER3 immediate early response 3
IL1B interleukin 1, beta
INHBA inhibin, beta A
ITFG1 integrin alpha FG-GAP repeat containing 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA6 integrin, alpha 6
LAMB3 laminin, beta 3
LIF leukemia inhibitory factor
LRP4 low density lipoprotein receptor-related protein 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NELL2 NEL-like 2 (chicken)
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PMEPA1 prostate transmembrane protein, androgen induced 1
PNMA2 paraneoplastic Ma antigen 2
PSD3 pleckstrin and Sec7 domain containing 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SATB2 SATB homeobox 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRY2 sprouty homolog 2 (Drosophila)
STX1A syntaxin 1A (brain)
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TGFA transforming growth factor, alpha
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TRIB3 tribbles pseudokinase 3
ZFP36L2 ZFP36 ring finger protein-like 2