BRD-K19687926_lapatinib_HME1_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K19687926_lapatinib_HME1_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANXA1 annexin A1
AQP1 aquaporin 1 (Colton blood group)
ARG2 arginase 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C10ORF10 chromosome 10 open reading frame 10
CD93 CD93 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLU clusterin
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
DPT dermatopontin
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EVL Enah/Vasp-like
EXOSC4 exosome component 4
GCLC glutamate-cysteine ligase, catalytic subunit
GIMAP6 GTPase, IMAP family member 6
GPX3 glutathione peroxidase 3
HEXIM1 hexamethylene bis-acetamide inducible 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IRS2 insulin receptor substrate 2
ITK IL2-inducible T-cell kinase
ITM2A integral membrane protein 2A
LGALS3 lectin, galactoside-binding, soluble, 3
LPL lipoprotein lipase
MAMLD1 mastermind-like domain containing 1
MGP matrix Gla protein
NR2F1 nuclear receptor subfamily 2, group F, member 1
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
RGCC regulator of cell cycle
SPEN spen family transcriptional repressor
TSC22D3 TSC22 domain family, member 3
TSPAN6 tetraspanin 6
TSPAN7 tetraspanin 7
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AQP9 aquaporin 9
AUTS2 autism susceptibility candidate 2
BCL2A1 BCL2-related protein A1
BMP2 bone morphogenetic protein 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHIC2 cysteine-rich hydrophobic domain 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FBN2 fibrillin 2
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GFPT2 glutamine-fructose-6-phosphate transaminase 2
HAS2 hyaluronan synthase 2
HIST1H2BK histone cluster 1, H2bk
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IL1B interleukin 1, beta
IL1R2 interleukin 1 receptor, type II
KDM5D lysine (K)-specific demethylase 5D
KDM6B lysine (K)-specific demethylase 6B
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LOX lysyl oxidase
NRIP1 nuclear receptor interacting protein 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PI3 peptidase inhibitor 3, skin-derived
PLAUR plasminogen activator, urokinase receptor
PRKCD protein kinase C, delta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
RGS4 regulator of G-protein signaling 4
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SOD2 superoxide dismutase 2, mitochondrial
STC1 stanniocalcin 1
TFPI2 tissue factor pathway inhibitor 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
ZC3H12A zinc finger CCCH-type containing 12A