BRD-K19687926_lapatinib_HME1_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K19687926_lapatinib_HME1_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADCY9 adenylate cyclase 9
AMIGO2 adhesion molecule with Ig-like domain 2
ASS1 argininosuccinate synthase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CA1 carbonic anhydrase I
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CD24 CD24 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFB complement factor B
CFD complement factor D (adipsin)
CLDN3 claudin 3
CLU clusterin
CNN1 calponin 1, basic, smooth muscle
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL8A2 collagen, type VIII, alpha 2
CREG1 cellular repressor of E1A-stimulated genes 1
CTSD cathepsin D
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCN decorin
DEGS1 delta(4)-desaturase, sphingolipid 1
DEPTOR DEP domain containing MTOR-interacting protein
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FABP1 fatty acid binding protein 1, liver
FADS1 fatty acid desaturase 1
FBLN1 fibulin 1
FBLN5 fibulin 5
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FTH1 ferritin, heavy polypeptide 1
FZD7 frizzled class receptor 7
GAA glucosidase, alpha; acid
GATA6 GATA binding protein 6
GLS glutaminase
GM2A GM2 ganglioside activator
GOLGA8B golgin A8 family, member B
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
GSE1 Gse1 coiled-coil protein
HEPH hephaestin
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPB1 heat shock 27kDa protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITGA8 integrin, alpha 8
LMOD1 leiomodin 1 (smooth muscle)
LUM lumican
MATN2 matrilin 2
MFAP5 microfibrillar associated protein 5
MSMO1 methylsterol monooxygenase 1
MXI1 MAX interactor 1, dimerization protein
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
NUAK1 NUAK family, SNF1-like kinase, 1
NUPR1 nuclear protein, transcriptional regulator, 1
PALLD palladin, cytoskeletal associated protein
PAWR PRKC, apoptosis, WT1, regulator
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
QPCT glutaminyl-peptide cyclotransferase
QPRT quinolinate phosphoribosyltransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
S100A10 S100 calcium binding protein A10
S100A8 S100 calcium binding protein A8
SC5D sterol-C5-desaturase
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFRP4 secreted frizzled-related protein 4
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPTSSA serine palmitoyltransferase, small subunit A
SQLE squalene epoxidase
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULF1 sulfatase 1
TAGLN transgelin
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TPM1 tropomyosin 1 (alpha)
TUBA1A tubulin, alpha 1a
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WNT5A wingless-type MMTV integration site family, member 5A
WT1 Wilms tumor 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AKAP7 A kinase (PRKA) anchor protein 7
ANXA10 annexin A10
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARPC5L actin related protein 2/3 complex, subunit 5-like
ATG3 autophagy related 3
AURKA aurora kinase A
BCL2A1 BCL2-related protein A1
CCND1 cyclin D1
CLDN10 claudin 10
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ETV1 ets variant 1
FGG fibrinogen gamma chain
FKBP11 FK506 binding protein 11, 19 kDa
HCAR3 hydroxycarboxylic acid receptor 3
HES1 hes family bHLH transcription factor 1
HMGA1 high mobility group AT-hook 1
KIF20A kinesin family member 20A
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MMP1 matrix metallopeptidase 1
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYO10 myosin X
NR2F6 nuclear receptor subfamily 2, group F, member 6
NT5E 5'-nucleotidase, ecto (CD73)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PITX1 paired-like homeodomain 1
PNP purine nucleoside phosphorylase
PSCA prostate stem cell antigen
S100P S100 calcium binding protein P
SMAGP small cell adhesion glycoprotein
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
TFF1 trefoil factor 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2S ubiquitin-conjugating enzyme E2S