BRD-K19540840_saracatinib_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

59 genes differentially expressed following the BRD-K19540840_saracatinib_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALG8 ALG8, alpha-1,3-glucosyltransferase
ANKRD10 ankyrin repeat domain 10
C3 complement component 3
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN2 chimerin 2
CPD carboxypeptidase D
DPP4 dipeptidyl-peptidase 4
ETV1 ets variant 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IFITM3 interferon induced transmembrane protein 3
PEG3 paternally expressed 3
PRR15L proline rich 15-like
SPINK1 serine peptidase inhibitor, Kazal type 1
TIAM1 T-cell lymphoma invasion and metastasis 1
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADGRL2 adhesion G protein-coupled receptor L2
AK1 adenylate kinase 1
BMP2 bone morphogenetic protein 2
CKS2 CDC28 protein kinase regulatory subunit 2
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
CYCS cytochrome c, somatic
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EGFR epidermal growth factor receptor
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FSTL1 follistatin-like 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER5 immediate early response 5
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IL13RA2 interleukin 13 receptor, alpha 2
KRT6A keratin 6A, type II
LGALS1 lectin, galactoside-binding, soluble, 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PLCB4 phospholipase C, beta 4
PLK2 polo-like kinase 2
RHOB ras homolog family member B
RND3 Rho family GTPase 3
SDC1 syndecan 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SESN1 sestrin 1
TAGLN2 transgelin 2
TCF4 transcription factor 4
TFPI2 tissue factor pathway inhibitor 2
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TRIP6 thyroid hormone receptor interactor 6
TUBB2A tubulin, beta 2A class IIa
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP6NL USP6 N-terminal like