BRD-K19540840_saracatinib_HCC515_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-K19540840_saracatinib_HCC515_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ANXA4 annexin A4
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BCL2L13 BCL2-like 13 (apoptosis facilitator)
C1S complement component 1, s subcomponent
C3 complement component 3
CAPN1 calpain 1, (mu/I) large subunit
CBR3 carbonyl reductase 3
CD36 CD36 molecule (thrombospondin receptor)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFB complement factor B
CFD complement factor D (adipsin)
CHRDL1 chordin-like 1
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
CTSA cathepsin A
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP2 epithelial membrane protein 2
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
HIST1H2AC histone cluster 1, H2ac
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
IFI27 interferon, alpha-inducible protein 27
IRF9 interferon regulatory factor 9
LRRC16A leucine rich repeat containing 16A
METTL7A methyltransferase like 7A
MUC1 mucin 1, cell surface associated
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
PDZK1IP1 PDZK1 interacting protein 1
PLD3 phospholipase D family, member 3
PPL periplakin
QPCT glutaminyl-peptide cyclotransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SOD2 superoxide dismutase 2, mitochondrial
SYBU syntabulin (syntaxin-interacting)
SYNE2 spectrin repeat containing, nuclear envelope 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF4 transmembrane 4 L six family member 4
TM7SF2 transmembrane 7 superfamily member 2
TMEM255A transmembrane protein 255A
TSPAN4 tetraspanin 4
TTC39A tetratricopeptide repeat domain 39A
VTCN1 V-set domain containing T cell activation inhibitor 1
VWA5A von Willebrand factor A domain containing 5A
XBP1 X-box binding protein 1
YBX3 Y box binding protein 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ANO1 anoctamin 1, calcium activated chloride channel
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
CA2 carbonic anhydrase II
CCND1 cyclin D1
CCNF cyclin F
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
DUSP2 dual specificity phosphatase 2
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EPHB2 EPH receptor B2
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EVI2A ecotropic viral integration site 2A
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
GATA2 GATA binding protein 2
GOLT1B golgi transport 1B
GPER1 G protein-coupled estrogen receptor 1
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HHEX hematopoietically expressed homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IGFBP3 insulin-like growth factor binding protein 3
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JUN jun proto-oncogene
KIAA0226L KIAA0226-like
LAMC2 laminin, gamma 2
LOXL2 lysyl oxidase-like 2
MECOM MDS1 and EVI1 complex locus
MMP12 matrix metallopeptidase 12
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLEK2 pleckstrin 2
PODXL podocalyxin-like
PSPH phosphoserine phosphatase
RGCC regulator of cell cycle
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMAD7 SMAD family member 7
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SYNJ2 synaptojanin 2
SYNM synemin, intermediate filament protein
TCF4 transcription factor 4
TGFBI transforming growth factor, beta-induced, 68kDa