BRD-K19295594_-666_HA1E_6.0_h_11.1_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K19295594_-666_HA1E_6.0_h_11.1_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADAM10 ADAM metallopeptidase domain 10
ADM adrenomedullin
AK4 adenylate kinase 4
APOD apolipoprotein D
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BBX bobby sox homolog (Drosophila)
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CBS cystathionine-beta-synthase
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHIC2 cysteine-rich hydrophobic domain 2
CTH cystathionine gamma-lyase
DARS aspartyl-tRNA synthetase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EDN1 endothelin 1
EGR3 early growth response 3
ENO2 enolase 2 (gamma, neuronal)
FAM13A family with sequence similarity 13, member A
FAM57A family with sequence similarity 57, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FLNB filamin B, beta
FOLR1 folate receptor 1 (adult)
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GDF15 growth differentiation factor 15
GPI glucose-6-phosphate isomerase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLF10 Kruppel-like factor 10
LGALS8 lectin, galactoside-binding, soluble, 8
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC4 mucin 4, cell surface associated
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
OXSR1 oxidative stress responsive 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
RALGDS ral guanine nucleotide dissociation stimulator
RHOB ras homolog family member B
RNASET2 ribonuclease T2
SARS seryl-tRNA synthetase
SH3YL1 SH3 and SYLF domain containing 1
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPAG4 sperm associated antigen 4
STC2 stanniocalcin 2
TGFA transforming growth factor, alpha
TNIP1 TNFAIP3 interacting protein 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
XBP1 X-box binding protein 1
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
CCNA2 cyclin A2
CCNF cyclin F
CPA3 carboxypeptidase A3 (mast cell)
CYTH1 cytohesin 1
GJA1 gap junction protein, alpha 1, 43kDa
H3F3B H3 histone, family 3B (H3.3B)
HN1 hematological and neurological expressed 1
HOXA10 homeobox A10
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
ICT1 immature colon carcinoma transcript 1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MECOM MDS1 and EVI1 complex locus
MEIS1 Meis homeobox 1
MRPS7 mitochondrial ribosomal protein S7
NUP85 nucleoporin 85kDa
PBX1 pre-B-cell leukemia homeobox 1
PRKCA protein kinase C, alpha
SEPP1 selenoprotein P, plasma, 1
SUMO2 small ubiquitin-like modifier 2
TARP TCR gamma alternate reading frame protein
TCF4 transcription factor 4
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
UBE2C ubiquitin-conjugating enzyme E2C
WBP5 WW domain binding protein 5