BRD-K19220233_JNK-9L_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

208 genes differentially expressed following the BRD-K19220233_JNK-9L_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK4 adenylate kinase 4
AKAP17A A kinase (PRKA) anchor protein 17A
ARFIP2 ADP-ribosylation factor interacting protein 2
ARMCX6 armadillo repeat containing, X-linked 6
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
BEX4 brain expressed, X-linked 4
CALB1 calbindin 1, 28kDa
CCL8 chemokine (C-C motif) ligand 8
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHERP calcium homeostasis endoplasmic reticulum protein
CIAPIN1 cytokine induced apoptosis inhibitor 1
COG2 component of oligomeric golgi complex 2
COL15A1 collagen, type XV, alpha 1
COL2A1 collagen, type II, alpha 1
CRISP3 cysteine-rich secretory protein 3
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSNK1D casein kinase 1, delta
CTSG cathepsin G
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
FASTKD5 FAST kinase domains 5
FOLR1 folate receptor 1 (adult)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GDE1 glycerophosphodiester phosphodiesterase 1
GDF15 growth differentiation factor 15
GPM6B glycoprotein M6B
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KCTD12 potassium channel tetramerization domain containing 12
LGALS2 lectin, galactoside-binding, soluble, 2
LMO4 LIM domain only 4
MAN2B1 mannosidase, alpha, class 2B, member 1
MAPK1 mitogen-activated protein kinase 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MICB MHC class I polypeptide-related sequence B
MIEF1 mitochondrial elongation factor 1
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NBPF10 neuroblastoma breakpoint family, member 10
NXN nucleoredoxin
PARM1 prostate androgen-regulated mucin-like protein 1
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PRPF4 pre-mRNA processing factor 4
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RIOK3 RIO kinase 3
RNF11 ring finger protein 11
RSL1D1 ribosomal L1 domain containing 1
S100A12 S100 calcium binding protein A12
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SEPHS2 selenophosphate synthetase 2
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SRSF11 serine/arginine-rich splicing factor 11
TCEAL4 transcription elongation factor A (SII)-like 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TSPAN3 tetraspanin 3
TUG1 taurine up-regulated 1 (non-protein coding)
UQCRH ubiquinol-cytochrome c reductase hinge protein
WAC WW domain containing adaptor with coiled-coil
WIPI1 WD repeat domain, phosphoinositide interacting 1
XPO7 exportin 7
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACAT2 acetyl-CoA acetyltransferase 2
ADAM10 ADAM metallopeptidase domain 10
ADGRG1 adhesion G protein-coupled receptor G1
ADI1 acireductone dioxygenase 1
ADIRF adipogenesis regulatory factor
AKAP7 A kinase (PRKA) anchor protein 7
ALCAM activated leukocyte cell adhesion molecule
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
ANXA7 annexin A7
AQP3 aquaporin 3 (Gill blood group)
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
BLMH bleomycin hydrolase
C10ORF10 chromosome 10 open reading frame 10
CASC3 cancer susceptibility candidate 3
CD36 CD36 molecule (thrombospondin receptor)
CD58 CD58 molecule
CDC25B cell division cycle 25B
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFD complement factor D (adipsin)
CHMP4A charged multivesicular body protein 4A
CLU clusterin
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL5A2 collagen, type V, alpha 2
CRIP1 cysteine-rich protein 1 (intestinal)
CSRP1 cysteine and glycine-rich protein 1
CXADR coxsackie virus and adenovirus receptor
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DEGS1 delta(4)-desaturase, sphingolipid 1
DENND2D DENN/MADD domain containing 2D
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DSP desmoplakin
DUT deoxyuridine triphosphatase
E2F2 E2F transcription factor 2
ECD ecdysoneless homolog (Drosophila)
EDNRB endothelin receptor type B
EGFR epidermal growth factor receptor
EMP1 epithelial membrane protein 1
EPCAM epithelial cell adhesion molecule
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM134B family with sequence similarity 134, member B
FKBP11 FK506 binding protein 11, 19 kDa
FXYD3 FXYD domain containing ion transport regulator 3
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GCHFR GTP cyclohydrolase I feedback regulator
GLRX glutaredoxin (thioltransferase)
GPX2 glutathione peroxidase 2
GSTA4 glutathione S-transferase alpha 4
HACD3 3-hydroxyacyl-CoA dehydratase 3
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)
HSPB1 heat shock 27kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IL1R1 interleukin 1 receptor, type I
IL7R interleukin 7 receptor
INHBA inhibin, beta A
INTS3 integrator complex subunit 3
ITM2A integral membrane protein 2A
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JCHAIN joining chain of multimeric IgA and IgM
JUP junction plakoglobin
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLF9 Kruppel-like factor 9
KRT15 keratin 15, type I
KRT18 keratin 18, type I
KRT5 keratin 5, type II
KRT8 keratin 8, type II
LXN latexin
LYPD3 LY6/PLAUR domain containing 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MEIS2 Meis homeobox 2
MUC5B mucin 5B, oligomeric mucus/gel-forming
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAPD3 non-SMC condensin II complex, subunit D3
NELL2 NEL-like 2 (chicken)
NET1 neuroepithelial cell transforming 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PLCB4 phospholipase C, beta 4
PLN phospholamban
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PSIP1 PC4 and SFRS1 interacting protein 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTS 6-pyruvoyltetrahydropterin synthase
RALB v-ral simian leukemia viral oncogene homolog B
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS1 regulator of G-protein signaling 1
RGS13 regulator of G-protein signaling 13
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RIN2 Ras and Rab interactor 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPA3 replication protein A3, 14kDa
SCARB1 scavenger receptor class B, member 1
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SRSF6 serine/arginine-rich splicing factor 6
STMN1 stathmin 1
SYBU syntabulin (syntaxin-interacting)
TACC2 transforming, acidic coiled-coil containing protein 2
TFF1 trefoil factor 1
THYN1 thymocyte nuclear protein 1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TMEM14A transmembrane protein 14A
TMEM255A transmembrane protein 255A
TMEM50A transmembrane protein 50A
TPM2 tropomyosin 2 (beta)
TRIM29 tripartite motif containing 29
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TUBA1A tubulin, alpha 1a
TWF2 twinfilin actin binding protein 2
TXN thioredoxin
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WIF1 WNT inhibitory factor 1
ZWILCH zwilch kinetochore protein