BRD-K19220233_JNK-9L_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-K19220233_JNK-9L_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD2 abhydrolase domain containing 2
AP3D1 adaptor-related protein complex 3, delta 1 subunit
CALD1 caldesmon 1
CD44 CD44 molecule (Indian blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHL1 cell adhesion molecule L1-like
CLDN10 claudin 10
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EAPP E2F-associated phosphoprotein
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
FLNA filamin A, alpha
FOLR1 folate receptor 1 (adult)
HBB hemoglobin, beta
IPO13 importin 13
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LAMC1 laminin, gamma 1 (formerly LAMB2)
LGALS1 lectin, galactoside-binding, soluble, 1
LRRC16A leucine rich repeat containing 16A
LTBP3 latent transforming growth factor beta binding protein 3
MAP1B microtubule-associated protein 1B
METRN meteorin, glial cell differentiation regulator
MMP11 matrix metallopeptidase 11
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
NEFH neurofilament, heavy polypeptide
NID2 nidogen 2 (osteonidogen)
PECR peroxisomal trans-2-enoyl-CoA reductase
PFKM phosphofructokinase, muscle
PRDX2 peroxiredoxin 2
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SH3BGR SH3 domain binding glutamate-rich protein
SYT1 synaptotagmin I
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TMEM8A transmembrane protein 8A
TSPAN7 tetraspanin 7
VCAN versican

decreased expression

Symbol Name
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
ALOX15B arachidonate 15-lipoxygenase, type B
ARHGAP29 Rho GTPase activating protein 29
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
ASS1 argininosuccinate synthase 1
AUTS2 autism susceptibility candidate 2
BCL6 B-cell CLL/lymphoma 6
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CCNA2 cyclin A2
CCNF cyclin F
CD163 CD163 molecule
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
CRABP1 cellular retinoic acid binding protein 1
CREB1 cAMP responsive element binding protein 1
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FAM46C family with sequence similarity 46, member C
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HSPH1 heat shock 105kDa/110kDa protein 1
IL18 interleukin 18
IRS2 insulin receptor substrate 2
KIF20A kinesin family member 20A
KLF4 Kruppel-like factor 4 (gut)
KLK5 kallikrein-related peptidase 5
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L2 NEDD4 binding protein 2-like 2
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PELI1 pellino E3 ubiquitin protein ligase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RPL37A ribosomal protein L37a
RPP38 ribonuclease P/MRP 38kDa subunit
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SAP30 Sin3A-associated protein, 30kDa
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SNX11 sorting nexin 11
SRSF7 serine/arginine-rich splicing factor 7
TARP TCR gamma alternate reading frame protein
TBX3 T-box 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFBR3 transforming growth factor, beta receptor III
TP53BP2 tumor protein p53 binding protein 2
TSC22D1 TSC22 domain family, member 1
TSC22D2 TSC22 domain family, member 2
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
USP1 ubiquitin specific peptidase 1
WEE1 WEE1 G2 checkpoint kinase